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Effect of Lonicera caerulea var. emphyllocalyx Fruit on Biofilm Formed by Porphyromonas gingivalis
Joint Authors
Minami, Masaaki
Nakamura, Mineo
Makino, Toshiaki
Takase, Hiroshi
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-10
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Porphyromonas gingivalis is an important pathogenic anaerobic bacterium that causes aspiration pneumonia.
This bacterium frequently forms biofilms in the oral cavity and in respiratory tract-associated medical devices.
Bacterial colonization that occurs in association with this biofilm formation is the main reason for incurable aspiration pneumonia.
The Lonicera caerulea var.
emphyllocalyx (LCE) fruit has been used in folk medicine in Hokkaido, the northern part of Japan.
The aim of this study was to elucidate one of the antimicrobial mechanisms of LCE methanol extract (LCEE)—the inhibitory effect of LCEE on biofilm formation by P.
gingivalis.
Our results show that LCEE significantly reduced biofilm formation by three different P.
gingivalis isolates in a concentration- and time-dependent manner that were quantified by the adsorption of safranin red.
When LCEE was added to biofilms already formed by P.
gingivalis, LCEE did not degrade the biofilm.
However, treatment with LCEE significantly promoted the removal of existing biofilm by vibration compared to that of control.
We also confirmed biofilm formation in LCEE-treated P.
gingivalis in tracheal tubes using scanning electron microscopic (SEM) analysis.
Cyanidin 3-O-glucoside (C3G), one of the components of LCE, also inhibited the formation of biofilm by P.
gingivalis in a concentration-dependent manner.
Our results reveal that LCEE may be an effective antibacterial substance for P.
gingivalis-induced aspiration pneumonia because of its role in the suppression of bacterial biofilm formation in the oral cavity.
American Psychological Association (APA)
Minami, Masaaki& Takase, Hiroshi& Nakamura, Mineo& Makino, Toshiaki. 2019. Effect of Lonicera caerulea var. emphyllocalyx Fruit on Biofilm Formed by Porphyromonas gingivalis. BioMed Research International،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1124657
Modern Language Association (MLA)
Minami, Masaaki…[et al.]. Effect of Lonicera caerulea var. emphyllocalyx Fruit on Biofilm Formed by Porphyromonas gingivalis. BioMed Research International No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1124657
American Medical Association (AMA)
Minami, Masaaki& Takase, Hiroshi& Nakamura, Mineo& Makino, Toshiaki. Effect of Lonicera caerulea var. emphyllocalyx Fruit on Biofilm Formed by Porphyromonas gingivalis. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1124657
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1124657