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Antitumor Effect of Albendazole on Cutaneous Squamous Cell Carcinoma (SCC) Cells
Joint Authors
Zhang, Qing-Ling
Li, Xue Mei
Lian, De-De
Zhu, Ming Ji
Jiang, Ri-Hua
Kim, Chang-Deok
Lee, Jae Kyung
Yoon, Tae-Jin
Lee, J.-H.
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-06-09
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Drug repurposing and/or repositioning is an alternative method to develop new treatment for certain diseases.
Albendazole was originally developed as an anthelmintic medication, and it has been used to treat a variety of parasitic infestations.
In this study, we investigated the antitumor effect of albendazole and putative action mechanism.
Results showed that albendazole dramatically decreased the cell viability of SCC cell lines (SCC12 and SCC13 cells).
Albendazole increased apoptosis-related signals, including cleaved caspase-3 and PARP-1 in a dose-dependent fashion.
The mechanistic study showed that albendazole induced endoplasmic reticulum (ER) stress, evidenced by increase of CHOP, ATF-4, caspase-4, and caspase-12.
Pretreatment with ER stress inhibitor 4-PBA attenuated albendazole-induced apoptosis of SCC cells.
In addition, albendazole decreased the colony-forming ability of SCC cells, together with inhibition of Wnt/β-catenin signaling.
These results indicate that albendazole shows an antitumor effect via regulation of ER stress and cancer stemness, suggesting that albendazole could be repositioned for cutaneous SCC treatment.
American Psychological Association (APA)
Zhang, Qing-Ling& Lian, De-De& Zhu, Ming Ji& Li, Xue Mei& Lee, Jae Kyung& Yoon, Tae-Jin…[et al.]. 2019. Antitumor Effect of Albendazole on Cutaneous Squamous Cell Carcinoma (SCC) Cells. BioMed Research International،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1124765
Modern Language Association (MLA)
Zhang, Qing-Ling…[et al.]. Antitumor Effect of Albendazole on Cutaneous Squamous Cell Carcinoma (SCC) Cells. BioMed Research International No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1124765
American Medical Association (AMA)
Zhang, Qing-Ling& Lian, De-De& Zhu, Ming Ji& Li, Xue Mei& Lee, Jae Kyung& Yoon, Tae-Jin…[et al.]. Antitumor Effect of Albendazole on Cutaneous Squamous Cell Carcinoma (SCC) Cells. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1124765
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1124765