Clinicopathologic and Prognostic Significance of Body Mass Index (BMI) among Breast Cancer Patients in Western China: A Retrospective Multicenter Cohort Based on Western China Clinical Cooperation Group (WCCCG)
Joint Authors
Ren, Guosheng
Zheng, Ke
Wang, Kang
Wu, Yu-Tuan
Zhang, Xiang
Chen, Li
Zhu, Wen-Ming
Zhang, Ai-Jie
Yin, Xue-Dong
Li, Fan
Kong, Ling-Quan
Ma, Bin-Lin
Li, Hui
Liu, Jin-Ping
Jiang, Jun
Li, Zhu-Yue
Shi, Yang
Li, Hong-Yuan
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-04-18
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Introduction.
Clinicopathologic and prognostic significance of body mass index (BMI) in breast cancer (BC) patients remained conflicting.
We aimed to investigate and modify the impact of BMI on clinicopathological significance and survival in western Chinese BC patients.
Materials and Methods.
8,394 female BC patients from Western China Clinical Cooperation Group (WCCCG) between 2005 and 2015 were identified.
Multivariable logistic regression and Cox proportion hazard regressions were used to examine the difference of clinicopathologic and survival characteristics between BMI categories.
Results.
For the premenopausal, overweight and obese (OW) patients tended to have large tumor size (>5cm) (odds ratio [OR], 1.30, P<0.01) and triple-negative BC (OR, 1.31; P=0.01) compared with normal weight (NW) patients.
Premenopausal underweight (UW) patients had a significantly higher risk of HER2 positive (OR, 1.71; P=0.02) and distant metastasis (OR, 2.59; P=0.01).
For postmenopausal patients, OW patients showed higher risks of large tumor size (>5cm) (OR, 1.46; P=0.01), nuclear grade III (OR, 1.24; P=0.04), and lymphovascular invasion (OR, 1.46; P=0.01) compared with NW patients.
An “U” shaped relationship between BMI and DFS was found (UW versus NW, adjusted hazard ratio (HR), 2.80, P<0.001; OW versus NW, adjusted HR, 1.40, P=0.02), whereas no significant difference of disease-free survival (DFS) between OW and NW premenopausal patients (adjusted HR=1.34, P=0.18) was revealed.
Conclusion.
We concluded that UW and OW were associated with aggressively clinicopathological characteristics, regardless of menopausal status.
An “U” shaped association of BMI and DFS was revealed, and no significant difference of DFS between OW and NW in postmenopausal subgroup was revealed.
American Psychological Association (APA)
Wang, Kang& Wu, Yu-Tuan& Zhang, Xiang& Chen, Li& Zhu, Wen-Ming& Zhang, Ai-Jie…[et al.]. 2019. Clinicopathologic and Prognostic Significance of Body Mass Index (BMI) among Breast Cancer Patients in Western China: A Retrospective Multicenter Cohort Based on Western China Clinical Cooperation Group (WCCCG). BioMed Research International،Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1124769
Modern Language Association (MLA)
Wang, Kang…[et al.]. Clinicopathologic and Prognostic Significance of Body Mass Index (BMI) among Breast Cancer Patients in Western China: A Retrospective Multicenter Cohort Based on Western China Clinical Cooperation Group (WCCCG). BioMed Research International No. 2019 (2019), pp.1-14.
https://search.emarefa.net/detail/BIM-1124769
American Medical Association (AMA)
Wang, Kang& Wu, Yu-Tuan& Zhang, Xiang& Chen, Li& Zhu, Wen-Ming& Zhang, Ai-Jie…[et al.]. Clinicopathologic and Prognostic Significance of Body Mass Index (BMI) among Breast Cancer Patients in Western China: A Retrospective Multicenter Cohort Based on Western China Clinical Cooperation Group (WCCCG). BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1124769
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1124769