Prevalence and Risk Factors of Reduced Bone Mineral Density in Systemic Lupus Erythematosus Patients: A Meta-Analysis
Joint Authors
Xia, Jumei
Luo, Ran
Guo, Shuiming
Yang, Yi
Ge, Shuwang
Xu, Gang
Zeng, Rui
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-20
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
We aimed to conduct a meta-analysis concerning the frequency and risk factors of reduced bone mineral density (BMD) in systemic lupus erythematosus (SLE) with evidence from published studies.
Methods.
A comprehensive literature search was conducted based on the EMBASE, Web of Science, PubMed, and Cochrane Library databases up to March 5th, 2017.
Eligible studies reported any prevalence of reduced BMD in SLE patients.
All risk factors with odds ratios or risk ratios associated with reduced BMD were extracted.
Results.
71 reports with 33527 SLE patients were included.
Low BMD, osteopenia, and osteoporosis at any site were presented, respectively, in 45%, 38%, and 13% of the SLE patients.
The prevalence of osteoporosis increased with the advancing of age, while U-shaped associations between age and the prevalence of low BMD and osteopenia were found.
Lumbar spine was indicated to have higher prevalence of osteoporosis.
Age, disease duration, drugs use, and many other factors were identified as predictors of reduced BMD.
Conclusion.
Low BMD, osteoporosis, and osteopenia appeared to be prevalent in patients with SLE.
Risk factors of reduced BMD were various.
American Psychological Association (APA)
Xia, Jumei& Luo, Ran& Guo, Shuiming& Yang, Yi& Ge, Shuwang& Xu, Gang…[et al.]. 2019. Prevalence and Risk Factors of Reduced Bone Mineral Density in Systemic Lupus Erythematosus Patients: A Meta-Analysis. BioMed Research International،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1124807
Modern Language Association (MLA)
Xia, Jumei…[et al.]. Prevalence and Risk Factors of Reduced Bone Mineral Density in Systemic Lupus Erythematosus Patients: A Meta-Analysis. BioMed Research International No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1124807
American Medical Association (AMA)
Xia, Jumei& Luo, Ran& Guo, Shuiming& Yang, Yi& Ge, Shuwang& Xu, Gang…[et al.]. Prevalence and Risk Factors of Reduced Bone Mineral Density in Systemic Lupus Erythematosus Patients: A Meta-Analysis. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1124807
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1124807