In Vitro Cytotoxicity and In Vivo Antimammary Tumor Effects of the Hydroethanolic Extract of Acacia seyal (Mimosaceae) Stem Bark
Joint Authors
Zingue, Stephane
Njuh, Amstrong Nang
Tueche, Alain Brice
Tamsa, Jeremie
Tchoupang, Edwige Nana
Kakene, Stanislas Djaouli
Sipping, Marius Trésor Kemegne
Njamen, Dieudonné
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-25
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The present study was designed to evaluate the in vitro and in vivo antitumor effects of A.
seyal hydroethanolic extract on breast cancer.
The cytotoxicity of A.
seyal extract was evaluated using resazurin reduction assay in 9 cell lines.
Further, the protective effect of the hydroethanolic extract of A.
seyal stem barks was evaluated on 7,12-dimethylbenz(a)anthracene- (DMBA-) induced breast cancer rat model.
Incidence, burden, volume, and histological analysis of mammary tumors were measured.
The Acacia seyal extract exhibited CC50 of 100 in MCF-7 cells after 24 h.
In vivo, no tumors were detected in rats from the control group, while 11 rats out of 12 (91.66%) developed mammary tumors in the DMBA-exposed group receiving only the vehicle.
Acacia seyal extract significantly (p<0.01) and in the dose-dependent manner reduced tumor incidence (3 rats out of 12 at the dose of 300 mg/kg), burden [62.1% (150 mg/kg) and 65.8% (300 mg/kg)], and mass.
It protected rats against DMBA-induced breast hyperplasia, with an optimal effect at the dose of 300 mg/kg.
Taken altogether, these results suggest that the hydroethanolic extract of Acacia seyal might contain phytoconstituents endowed with antitumoral properties, which could protect against the breast cancer induced in rats.
American Psychological Association (APA)
Zingue, Stephane& Njuh, Amstrong Nang& Tueche, Alain Brice& Tamsa, Jeremie& Tchoupang, Edwige Nana& Kakene, Stanislas Djaouli…[et al.]. 2018. In Vitro Cytotoxicity and In Vivo Antimammary Tumor Effects of the Hydroethanolic Extract of Acacia seyal (Mimosaceae) Stem Bark. BioMed Research International،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1124836
Modern Language Association (MLA)
Zingue, Stephane…[et al.]. In Vitro Cytotoxicity and In Vivo Antimammary Tumor Effects of the Hydroethanolic Extract of Acacia seyal (Mimosaceae) Stem Bark. BioMed Research International No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1124836
American Medical Association (AMA)
Zingue, Stephane& Njuh, Amstrong Nang& Tueche, Alain Brice& Tamsa, Jeremie& Tchoupang, Edwige Nana& Kakene, Stanislas Djaouli…[et al.]. In Vitro Cytotoxicity and In Vivo Antimammary Tumor Effects of the Hydroethanolic Extract of Acacia seyal (Mimosaceae) Stem Bark. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1124836
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1124836