Effects of Cervical Rotatory Manipulation (CRM) on Carotid Atherosclerosis Plaque in Vulnerability: A Histological and Immunohistochemical Study Using Animal Model
Joint Authors
Zhang, Shaoqun
Qi, Ji
Ping, Ruiyue
Xu, Yanxiao
Wu, Kai
Li, Yikai
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-04
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
The safety of cervical rotatory manipulation (CRM) is still controversial, especially in patients with carotid artery atherosclerosis (CAS).
The study aimed to investigate the effects of CRM on carotid plaques in vulnerability.
Methods.
50 rabbits were randomly divided into four groups: model rabbits with CRM [CAS-CRM (n=15)]; model rabbits without CRM [CAS (n=15)]; normal rabbits with CRM [Normal-CRM (n=10)]; and Blank-control group (n=10).
CAS disease models were induced by carotid artery balloon injury combined with a high-fat diet for 12 weeks.
Then, CRM technique was performed in CAS-CRM and Normal-CRM groups for 3 weeks.
In the end, determination of serum level of hs-CRP and Lp-PLA2, histological analysis under HE and Masson trichromic staining, and immunohistochemical analysis with CD34 and CD68 antibody were completed in order.
Results.
Carotid stenosis rates on successful model rabbits ranged from 70% to 98%.
The CAS-CRM group had an increased level of hs-CRP (P<0.05), in comparison with the CAS group, whereas effects were not significant between the Normal-CRM group and Blank-control group.
In comparison with the CAS group, the positive expression of CD34 and CD68 in the CAS-CRM group increased significantly (P<0.05).
Conclusion.
CRM therapy may increase the vulnerability of carotid plaque in rabbits with severe CAS.
American Psychological Association (APA)
Qi, Ji& Ping, Ruiyue& Zhang, Shaoqun& Xu, Yanxiao& Wu, Kai& Li, Yikai. 2019. Effects of Cervical Rotatory Manipulation (CRM) on Carotid Atherosclerosis Plaque in Vulnerability: A Histological and Immunohistochemical Study Using Animal Model. BioMed Research International،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1124838
Modern Language Association (MLA)
Qi, Ji…[et al.]. Effects of Cervical Rotatory Manipulation (CRM) on Carotid Atherosclerosis Plaque in Vulnerability: A Histological and Immunohistochemical Study Using Animal Model. BioMed Research International No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1124838
American Medical Association (AMA)
Qi, Ji& Ping, Ruiyue& Zhang, Shaoqun& Xu, Yanxiao& Wu, Kai& Li, Yikai. Effects of Cervical Rotatory Manipulation (CRM) on Carotid Atherosclerosis Plaque in Vulnerability: A Histological and Immunohistochemical Study Using Animal Model. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1124838
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1124838