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Reference Intervals of Thyroid Hormones and Correlation of BMI with Thyroid Function in Healthy Zhuang Ethnic Pregnant Women
Joint Authors
Liu, Shun
Sheng, Yonghong
Huang, Dongping
Guo, Xuefeng
Chen, Jiehua
Shao, Yantao
Zhang, Guoqiang
Wei, Liangjia
Zeng, Xiaoyun
Qiu, Xiaoqiang
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-11-14
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Ethnic differences in the level of thyroid hormones exist among individuals.
The American Thyroid Association (ATA) recommends that an institution or region should establish a specific thyroid hormone reference value for each stage of pregnancy.
To date, a limited number of studies have reported the level of thyroid hormones in Chinese minorities, and the exact relationship between BMI and thyroid function in pregnant women is ill.
This study was performed to establish trimester-specific reference ranges of thyroid hormones in Zhuang ethnic pregnant women and explore the role of body mass index (BMI) on thyroid function.
A total of 3324 Zhuang ethnic health pregnant women were recruited in this Zhuang population-based retrospective cross-sectional study.
The values of thyroid stimulating hormone (TSH), free thyroxine (FT4), and free triiodothyronine (FT3) were determined by automatic chemiluminescence immunoassay analyzer.
Multivariate linear regression and binary logistic regression were constructed to evaluate the influence of BMI on the thyroid function.
The established reference intervals for the serum thyroid hormones in three trimesters were as follows: TSH, 0.02–3.28, 0.03–3.22, and 0.08-3.71 mIU/L; FT4, 10.57–19.76, 10.05–19.23, and 8.96–17.75 pmol/L; FT3, 3.51–5.64, 3.42–5.42, and 2.93–5.03 pmol/L.
These values were markedly lower than those provided by the manufacturers for nonpregnant adults which can potentially result in 6.10% to 19.73% misclassification in Zhuang pregnant women.
Moreover, BMI was positively correlated with isolated hypothyroxinemia (OR=1.081, 95% CI=1.007–1.161), while the correlation between the BMI and subclinical hypothyroidism was not statistically significant (OR=0.991, 95% CI=0.917–1.072).
This is the first study focusing on the reference ranges of thyroid hormones in Guangxi Zhuang ethnic pregnant women, which will improve the care of them in the diagnosis and treatment.
We also found that high BMI was positively associated with the risk of isolated hypothyroxinemia.
American Psychological Association (APA)
Sheng, Yonghong& Huang, Dongping& Liu, Shun& Guo, Xuefeng& Chen, Jiehua& Shao, Yantao…[et al.]. 2018. Reference Intervals of Thyroid Hormones and Correlation of BMI with Thyroid Function in Healthy Zhuang Ethnic Pregnant Women. BioMed Research International،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1124839
Modern Language Association (MLA)
Sheng, Yonghong…[et al.]. Reference Intervals of Thyroid Hormones and Correlation of BMI with Thyroid Function in Healthy Zhuang Ethnic Pregnant Women. BioMed Research International No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1124839
American Medical Association (AMA)
Sheng, Yonghong& Huang, Dongping& Liu, Shun& Guo, Xuefeng& Chen, Jiehua& Shao, Yantao…[et al.]. Reference Intervals of Thyroid Hormones and Correlation of BMI with Thyroid Function in Healthy Zhuang Ethnic Pregnant Women. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1124839
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1124839