House Mice as a Real Sanitary Threat of Human and Animal Leptospirosis: Proposal for Integrated Management
Joint Authors
Marquez, Aurélie
Ulivieri, Tristan
Benoit, Etienne
Lattard, Virginie
Kodjo, Angeli
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-06-23
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Leptospirosis is a reemerging zoonosis and ranges in severity from benign to sometimes fatal.
In cattle, infection may be responsible for abortion and infertility cases causing economic losses.
Humans may be contaminated through direct contact with urine of infected animals or indirectly though interaction with urine-contaminated environment.
Many wildlife species living close to cattle, especially commensal rodents may play a role in the transmission of leptospires.
Because little is known on the epidemiology of nonmaintenance Leptospira serovars, appropriate management is still limited.
On a French farm where human and cattle leptospirosis were detected, the transmission cycle was explored to propose appropriate mitigation measures.
For that, commensal rodents present on the farm were trapped and their leptospires carriage was studied by molecular methods.
Trapped mice were shown to carry two pathogenic Leptospira species (L.
interrogans and L.
kirschneri).
Since these 2 serogroups were simultaneously detected in the trapped mice and in the cows of this farm, we suspected an initial Leptospira transmission from mice to cows requiring an effective management of mice on this farm.
Because resistance to anticoagulant rodenticides due to Vkorc1 mutations has been largely described in rodents and first-generation anticoagulant rodenticides seemed to be inefficient in controlling mice on this farm, susceptibility of these mice to anticoagulants has been characterized by Vkorc1 sequencing.
50% of the trapped mice carried mutations in the Vkorc1 gene leading to severe resistance to first-generation anticoagulants.
The management of such mice that are a real sanitary threat can be achieved only by using the most toxic second-generation anticoagulants or nonanticoagulant solutions.
American Psychological Association (APA)
Marquez, Aurélie& Ulivieri, Tristan& Benoit, Etienne& Kodjo, Angeli& Lattard, Virginie. 2019. House Mice as a Real Sanitary Threat of Human and Animal Leptospirosis: Proposal for Integrated Management. BioMed Research International،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1124848
Modern Language Association (MLA)
Marquez, Aurélie…[et al.]. House Mice as a Real Sanitary Threat of Human and Animal Leptospirosis: Proposal for Integrated Management. BioMed Research International No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1124848
American Medical Association (AMA)
Marquez, Aurélie& Ulivieri, Tristan& Benoit, Etienne& Kodjo, Angeli& Lattard, Virginie. House Mice as a Real Sanitary Threat of Human and Animal Leptospirosis: Proposal for Integrated Management. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1124848
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1124848