Aldose Reductase Inhibitors of Plant Origin in the Prevention and Treatment of Alcoholic Liver Disease: A Minireview

Joint Authors

Qiu, Long-Xin
Guo, Chang
Hua, Baoyu

Source

BioMed Research International

Issue

Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2019-06-20

Country of Publication

Egypt

No. of Pages

8

Main Subjects

Medicine

Abstract EN

Alcoholic liver disease (ALD) is caused by heavy alcohol consumption over a long period.

Acetaldehyde-mediated toxicity, oxidative stress, and imbalance of lipid metabolism are generally considered involved in the initiation of ALD.

There is an increasing requirement for alternative and natural medicine to treat ALD.

Recently, aldose reductase (AR) has been reported to be involved in the development of ALD by affecting inflammatory cytokines, oxidative stress, and lipid metabolism.

Here, we review the effect of plant-derived AR inhibitors on ALD in rodents.

And we conclude that AR inhibitors of plant origin may enhance antioxidant capacity, inhibit lipid peroxidation and inflammatory cytokines expression, and activate AMP-activated protein kinase thereby subsequently suppressing alcohol-induced lipid synthesis in liver to achieve ALD protection.

This review reveals that natural AR inhibitor may be potential therapeutic agent for ALD.

American Psychological Association (APA)

Qiu, Long-Xin& Guo, Chang& Hua, Baoyu. 2019. Aldose Reductase Inhibitors of Plant Origin in the Prevention and Treatment of Alcoholic Liver Disease: A Minireview. BioMed Research International،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1124860

Modern Language Association (MLA)

Qiu, Long-Xin…[et al.]. Aldose Reductase Inhibitors of Plant Origin in the Prevention and Treatment of Alcoholic Liver Disease: A Minireview. BioMed Research International No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1124860

American Medical Association (AMA)

Qiu, Long-Xin& Guo, Chang& Hua, Baoyu. Aldose Reductase Inhibitors of Plant Origin in the Prevention and Treatment of Alcoholic Liver Disease: A Minireview. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1124860

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1124860