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The Impact of Lactobacillus plantarum on the Gut Microbiota of Mice with DSS-Induced Colitis
Joint Authors
Bi, Ding-Ren
Zhang, Fei
Li, Yue
Wang, Xiliang
Wang, Shengping
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-20
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The pathogenesis of inflammatory bowel disease (IBD) is due in part to a loss of equilibrium among the gut microbiota, epithelial cells, and resident immune cells.
The gut microbiota contains a large proportion of probiotic commensal Lactobacillus species; some natural microbiota and probiotics confer protection against IBD.
In this study, mice with colitis triggered by dextran sodium sulphate (DSS) were given Lactobacillus plantarum orally.
We assessed the damage caused by DSS and the therapeutic activity of L.
plantarum.
The colitis triggered by DSS was less severe in the mice that received the L.
plantarum treatment, which also diversified the microbe species in the colon, enhanced the ratio of Firmicutes to Bacteroidetes, and diminished the relative abundance of Lactobacillus.
The taxonomic units of greatest diversity in the DSS and L.
plantarum groups were identified using a linear discriminant and effect size (LEfSe) analysis.
Aliihoeflea was established to be the genus of bacteria that was affected in the L.
plantarum group most extensively.
In conclusion, gut health was promoted by L.
plantarum, as it diversified the microbes in the colon and restricted the activity of pathogenic bacteria in the intestine.
Moreover, according to the LEfSe analysis, the DSS group was impacted more significantly by gut microorganisms than the L.
plantarum group, suggesting that L.
plantarum improved the stability of the intestinal tract.
American Psychological Association (APA)
Zhang, Fei& Li, Yue& Wang, Xiliang& Wang, Shengping& Bi, Ding-Ren. 2019. The Impact of Lactobacillus plantarum on the Gut Microbiota of Mice with DSS-Induced Colitis. BioMed Research International،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1124970
Modern Language Association (MLA)
Zhang, Fei…[et al.]. The Impact of Lactobacillus plantarum on the Gut Microbiota of Mice with DSS-Induced Colitis. BioMed Research International No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1124970
American Medical Association (AMA)
Zhang, Fei& Li, Yue& Wang, Xiliang& Wang, Shengping& Bi, Ding-Ren. The Impact of Lactobacillus plantarum on the Gut Microbiota of Mice with DSS-Induced Colitis. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1124970
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1124970