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Zika Virus Targeting by Screening Inhibitors against NS2BNS3 Protease
Joint Authors
Ali, Ashraf
Choudhry, Hani
Hassan, Mohammed A.
Zamzami, Mazin A.
Alzahrani, Faisal A.
Alghamdi, Asma
Abdulaal, Wesam H.
Bakhrebah, Muhammed A.
Helmi, Nawal
Bokhari, Fawzi F.
Zeyadi, Mustafa
Baothman, Othman A.
Kamal, Mohammad A.
Warsi, Mohiuddin K.
Jarullah, Bushra
Jamal, Mohammad S.
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-22
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Zika flavivirus is suspected to cause Guillain-Barre syndrome in adults and microcephaly, along with other congenital abnormalities in infants.
Presently, no vaccines or therapeutics are available.
Here, we report novel compounds identified by high-throughput virtual screening of Maybridge chemical database and molecular docking studies.
We selected viral enzyme NS2B/NS3 serine protease as the therapeutic target because of its important role in viral replication.
We selected seven potential compounds as antiviral drug candidates because of their high GOLD fitness score, high AutoDock Vina score, or X-Score binding energy and analyzed the strength of molecular interactions between the active site amino acids and selected compounds.
Our study also provides a foundation for similar studies for the search of novel therapeutics against Zika virus.
American Psychological Association (APA)
Choudhry, Hani& Alzahrani, Faisal A.& Hassan, Mohammed A.& Alghamdi, Asma& Abdulaal, Wesam H.& Bakhrebah, Muhammed A.…[et al.]. 2019. Zika Virus Targeting by Screening Inhibitors against NS2BNS3 Protease. BioMed Research International،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1124993
Modern Language Association (MLA)
Choudhry, Hani…[et al.]. Zika Virus Targeting by Screening Inhibitors against NS2BNS3 Protease. BioMed Research International No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1124993
American Medical Association (AMA)
Choudhry, Hani& Alzahrani, Faisal A.& Hassan, Mohammed A.& Alghamdi, Asma& Abdulaal, Wesam H.& Bakhrebah, Muhammed A.…[et al.]. Zika Virus Targeting by Screening Inhibitors against NS2BNS3 Protease. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1124993
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1124993