The Impact of Steatosis on the Outcome of Liver Transplantation: A Meta-Analysis
Joint Authors
Zhang, Qiongfang
Zhang, Qiong-Yue
Zhang, Da-Zhi
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-05-14
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background and Aims.
Liver transplantation is one of the most effective treatments for end-stage liver disease as well as for cases of acute liver failure.
Facing organ donor shortage, liver transplant teams had to use marginal organs.
Thus, increasing availability is a key concern of donor liver grafts including steatotic livers.
However, the use of steatotic liver is still controversial.
The aim of this systematic review and meta-analysis was to analyze the impact of steatosis on the outcome of liver transplantation.
Methods.
We searched PubMed, Cochrane Library, Embase, Web of knowledge, and so on for studies published through May 31, 2018, in which patients experienced liver transplantation using fatty liver.
All studies extracted outcome indicators, and we draw conclusions by contrasting outcome indicators in different groups of steatosis.
Odds ratios and 95% confidence intervals were calculated.
P<0.05 was considered as statistically significant difference.
Results.
19 publications were included.
There was no significant difference between the group of no steatosis and mild group in primary nonfunction rate (P=0.605) or early graft dysfunction rate (P=0.44).
The PNF rate was significantly higher in moderate group (P=0.003) and severe group (P <0.001) compared with that in no steatosis group.
The same results were seen in early graft dysfunction rate.
However, graft survival rate and patient survival rate did not differ between groups.
Conclusions.
Livers with mild steatosis, even with moderate or severe steatosis, could be suitable donor under strict control of transplant conditions.
American Psychological Association (APA)
Zhang, Qiong-Yue& Zhang, Qiongfang& Zhang, Da-Zhi. 2019. The Impact of Steatosis on the Outcome of Liver Transplantation: A Meta-Analysis. BioMed Research International،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1125018
Modern Language Association (MLA)
Zhang, Qiong-Yue…[et al.]. The Impact of Steatosis on the Outcome of Liver Transplantation: A Meta-Analysis. BioMed Research International No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1125018
American Medical Association (AMA)
Zhang, Qiong-Yue& Zhang, Qiongfang& Zhang, Da-Zhi. The Impact of Steatosis on the Outcome of Liver Transplantation: A Meta-Analysis. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1125018
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1125018