Prognostic Significance of MicroRNAs in Glioma: A Systematic Review and Meta-Analysis
Joint Authors
Wang, Junyu
Hou, Lijun
Chen, Jigang
Zhang, Yanming
Xue, Qiang
Zhao, Liang
Han, Kaiwei
Zhang, Danfeng
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-03-26
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Purpose.
Different microRNAs (miRs) have been demonstrated to relate with the outcome of glioma patients, while the conclusions are inconsistent.
We perform a meta-analysis to clarify the relationship between different miRs and prognosis of glioma.
Methods.
Related studies were retrieved from PubMed, Embase, and Cochrane Library.
Pooled hazard ratios (HRs) of different miRs expression for survival and 95% confidence intervals (CIs) were calculated using random-effects model.
Results.
A total of 15 miRs with 4708 glioma patients were ultimately included.
Increased expression of miR-15b (HR, 1.584; 95% CI, 1.199-2.092), 21 (HR, 1.591; 95% CI, 1.278-1.981), 148a (HR, 1.122; 95% CI, 1.023-1.231), 196 (HR, 1.877; 95% CI, 1.033-3.411), 210 (HR, 1.251; 95% CI, 1.010-1.550), and 221 (HR, 1.269; 95% CI, 1.054-1.527) or decreased expression of miR-106a (HR, 0.809; 95% CI, 0.655-0.998) and 124 (HR, 0.833; 95% CI, 0.729-0.952) was correlated with poor outcome of glioma patients.
Conclusions.
miR-15b, 21, 148a, 196, 210, 221, 106a, and 124 are valuable biomarkers for the prognosis of glioma which might be used in clinical settings.
American Psychological Association (APA)
Zhang, Yanming& Chen, Jigang& Xue, Qiang& Wang, Junyu& Zhao, Liang& Han, Kaiwei…[et al.]. 2019. Prognostic Significance of MicroRNAs in Glioma: A Systematic Review and Meta-Analysis. BioMed Research International،Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1125059
Modern Language Association (MLA)
Zhang, Yanming…[et al.]. Prognostic Significance of MicroRNAs in Glioma: A Systematic Review and Meta-Analysis. BioMed Research International No. 2019 (2019), pp.1-14.
https://search.emarefa.net/detail/BIM-1125059
American Medical Association (AMA)
Zhang, Yanming& Chen, Jigang& Xue, Qiang& Wang, Junyu& Zhao, Liang& Han, Kaiwei…[et al.]. Prognostic Significance of MicroRNAs in Glioma: A Systematic Review and Meta-Analysis. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1125059
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1125059