Protective Effect of the MCP-1 Gene Haplotype against Schizophrenia
Joint Authors
Saoud, Hana
Inoubli, Oumaima
Ben Fredj, Sihem
Hassine, Mohsen
Ben Mohamed, Bochra
Gaha, Lotfi
Hadj Jrad, Besma Bel
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-02
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
While cytokines and their genetic variants have been intensively studied in schizophrenia, little attention has been focused on chemokines in the last years.
The monocyte chemoattractant protein 1 (MCP-1) is known to attract peripheral monocytes to the brain during an inflammatory reaction and to affect the T helper (Th) cell development by stimulating Th2 polarization.
Owing to the neuroinflammation in schizophrenia and the variable level of MCP-1 in these patients’ sera, we proposed to analyze the impact of functional genetic variants of the MCP-1 gene (MCP-1-2518A/G (rs1024611), MCP-1-362G/C (rs2857656), and MCP-1 int1del554-567 (rs3917887)) in schizophrenic patients.
We conducted a case-control study on a Tunisian population composed of 200 patients and 200 controls using RFLP-PCR.
Our results indicated that the minor alleles (-2518G and Del554-567) were significantly more prevalent in controls than in patients (P=0.001/adjusted OR = 0.42, P=0.04/adjusted OR = 0.64), whereas, for -362C minor allele, increased risk of schizophrenia was revealed (P=0.001, adjusted OR = 2.38).
In conclusion, we have identified the haplotype combination -2581G/-362G/int1del554-567 that could mediate protection against schizophrenia (P=0.0038, OR = 0.19) and the effect could result more strongly from the MCP-1 -2582G with -362G variants, whereas the effect of int1del554-567 may in part be explained by its LD with -362.
American Psychological Association (APA)
Saoud, Hana& Inoubli, Oumaima& Ben Fredj, Sihem& Hassine, Mohsen& Ben Mohamed, Bochra& Gaha, Lotfi…[et al.]. 2019. Protective Effect of the MCP-1 Gene Haplotype against Schizophrenia. BioMed Research International،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1125083
Modern Language Association (MLA)
Saoud, Hana…[et al.]. Protective Effect of the MCP-1 Gene Haplotype against Schizophrenia. BioMed Research International No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1125083
American Medical Association (AMA)
Saoud, Hana& Inoubli, Oumaima& Ben Fredj, Sihem& Hassine, Mohsen& Ben Mohamed, Bochra& Gaha, Lotfi…[et al.]. Protective Effect of the MCP-1 Gene Haplotype against Schizophrenia. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1125083
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1125083