Protective Effect of Citrulline on the Hearts of Rats with Sepsis Induced by Cecal Ligation and Puncture
Joint Authors
Cai, Bin
Luo, Yu-long
Zhou, Ji-qiu
Xu, Xiong
Zhen, Wei-wei
Zhang, Sen
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-10-18
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Purpose.
To investigate the protective effect of citrulline (Cit) on the hearts of rats with sepsis.
Methods.
Wistar rats were divided into the normal, sham-operated, CLP, Cit, and CLP+Cit groups.
Routine blood tests were performed, and the blood biochemical indexes were measured.
Pathological changes in the cardiac tissues were observed.
The levels of NO and iNOS in blood and SOD activity and MDA levels in the heart were measured.
Results.
Less inflammatory cell infiltration of the myocardial fibers and significantly decreased white blood cell count, absolute neutrophil count, neutrophil percentage, CK, HBDH, and NO (all P<0.05) were detected in the CLP+Cit group compared with the CLP group.
In addition, SOD activity and MDA levels in heart tissues were, respectively, higher and lower in the CLP+Cit group than in the CLP group (both P<0.05).
Conclusions.
Cit reduces pathological damage in the heart and enhances the heart’s antioxidant capacity, thereby protecting cardiomyocytes.
American Psychological Association (APA)
Zhou, Ji-qiu& Xu, Xiong& Zhen, Wei-wei& Luo, Yu-long& Cai, Bin& Zhang, Sen. 2018. Protective Effect of Citrulline on the Hearts of Rats with Sepsis Induced by Cecal Ligation and Puncture. BioMed Research International،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1125120
Modern Language Association (MLA)
Zhou, Ji-qiu…[et al.]. Protective Effect of Citrulline on the Hearts of Rats with Sepsis Induced by Cecal Ligation and Puncture. BioMed Research International No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1125120
American Medical Association (AMA)
Zhou, Ji-qiu& Xu, Xiong& Zhen, Wei-wei& Luo, Yu-long& Cai, Bin& Zhang, Sen. Protective Effect of Citrulline on the Hearts of Rats with Sepsis Induced by Cecal Ligation and Puncture. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1125120
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1125120