Effects of Melatonin on Intestinal Microbiota and Oxidative Stress in Colitis Mice
Joint Authors
Fang, Jun
Jiang, Hongmei
Zhu, Dan
Ma, Yong
Ding, Sujuan
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-06
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
This study investigated the antioxidant capacity and intestinal bacteria community in a mouse model of DSS-induced colitis.
Twenty mice were randomly assigned to two treatments: mice with colitis induced by 5% DSS (DSS group) and mice with colitis induced by 5% DSS that also received melatonin treatment (MEL group).
The DSS group showed significantly less antioxidant capability than the MEL group, but the two groups did not differ significantly in terms of diversity index (Shannon and Simpson), bacterial culture abundance (Chao1 and ACE), and coverage (Good’s coverage estimator).
Bacteroidetes were the most abundant phylum in the DSS group (58.93%), followed by Firmicutes with 31.46% and Proteobacteria with 7.97%.
In contrast, Firmicutes were the most abundant in the MEL group (49.48%), followed by Bacteroidetes with 41.63% and Proteobacteria with 7.50%.
The results support the use of melatonin for prevention of intestinal bowel disease due to its modulatory effect on antioxidant capability and microbiota in mice with colitis.
Melatonin was demonstrated to improve the oxidative stress resistance of mice with colitis and regulate the intestinal microbial flora, thus improving intestinal health.
American Psychological Association (APA)
Zhu, Dan& Ma, Yong& Ding, Sujuan& Jiang, Hongmei& Fang, Jun. 2018. Effects of Melatonin on Intestinal Microbiota and Oxidative Stress in Colitis Mice. BioMed Research International،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1125146
Modern Language Association (MLA)
Zhu, Dan…[et al.]. Effects of Melatonin on Intestinal Microbiota and Oxidative Stress in Colitis Mice. BioMed Research International No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1125146
American Medical Association (AMA)
Zhu, Dan& Ma, Yong& Ding, Sujuan& Jiang, Hongmei& Fang, Jun. Effects of Melatonin on Intestinal Microbiota and Oxidative Stress in Colitis Mice. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1125146
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1125146