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Effect of Chronic Kidney Disease on Changes in Vasopressin System Expression in the Kidney Cortex in Rats with Nephrectomy
Joint Authors
Puchalska, L.
Niemczyk, Stanisław
Saracyn, Marek
Niemczyk, Longin
Wrzesien, Robert
Tkaczyk, Marzanna
Zmudzki, Wawrzyniec
Cudnoch-Jedrzejewska, A.
Czarzasta, K.
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-14
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
It is believed that the vasopressinergic system plays an important role in the pathogenesis of chronic kidney disease (CKD).
The aim of this study was to evaluate the effect of CKD on changes in vasopressin system expression in the kidney cortex in rats with nephrectomy.
The study was performed on 4 groups of Sprague Dawley (SPRD) rats: a control group (CN), 1/2 nephrectomy (N1/2), 2/3 nephrectomy (N2/3), and 5/6 nephrectomy (N5/6).
Blood and the kidney cortex were collected to evaluate plasma copeptin concentrations and mRNA expressions of V1a vasopressin receptors (V1aR) and V2 vasopressin receptors (V2R) and V1aR, V2R, and aquaporin 2 (AQP2) protein levels.
V1aR and V2R mRNA expression in the kidney cortex was significantly lower in the CN group compared with the other groups.
In contrast, the V1aR, V2R, and AQP2 protein levels were significantly higher in the CN group compared with all of the nephrectomized groups.
Plasma copeptin concentration was significantly lower in the CN group than in the nephrectomized groups.
CKD caused significant changes in the expression of the vasopressinergic system.
Further research is needed to explain the mechanisms of the impact of the vasopressinergic system on the kidney in CKD.
American Psychological Association (APA)
Czarzasta, K.& Cudnoch-Jedrzejewska, A.& Niemczyk, Longin& Wrzesien, Robert& Tkaczyk, Marzanna& Puchalska, L.…[et al.]. 2018. Effect of Chronic Kidney Disease on Changes in Vasopressin System Expression in the Kidney Cortex in Rats with Nephrectomy. BioMed Research International،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1125148
Modern Language Association (MLA)
Czarzasta, K.…[et al.]. Effect of Chronic Kidney Disease on Changes in Vasopressin System Expression in the Kidney Cortex in Rats with Nephrectomy. BioMed Research International No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1125148
American Medical Association (AMA)
Czarzasta, K.& Cudnoch-Jedrzejewska, A.& Niemczyk, Longin& Wrzesien, Robert& Tkaczyk, Marzanna& Puchalska, L.…[et al.]. Effect of Chronic Kidney Disease on Changes in Vasopressin System Expression in the Kidney Cortex in Rats with Nephrectomy. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1125148
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1125148