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Aberrantly Expressed Genes and miRNAs in Slow Transit Constipation Based on RNA-Seq Analysis
Joint Authors
Zhao, Shipeng
Chen, Qiang
Kang, Xianwu
Kong, Bin
Wang, Zhuo
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-08-14
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Background.
This study aims to identify the key genes and miRNAs in slow transit constipation (STC).
Methods.
MRNA and miRNA expression profiling were obtained.
Differentially expressed genes (DEGs) and miRNAs were identified followed by the regulatory network construction.
Functional annotation analysis and protein-protein interaction (PPI) network were conducted.
The electronic validation was performed.
Results.
Hsa-miR-2116-3p, hsa-miR-3622a-5p, hsa-miR-424-5p, and hsa-miR-1273-3p covered most DEGs.
HLA-DRB1, HLA-DRB5, C3, and ICAM were significantly involved in staphylococcus aureus infection.
The PPI network generated several hub proteins including ZBTB16, FBN1, CCNF, and CDK1.
Electronic validation of HLA-DRB1, PTGDR, MKI67, BIRC5, CCNF, and CDK1 was consistent with the RNA-sequencing analysis.
Conclusion.
Our study might be helpful in understanding the pathology of STC at the molecular level.
American Psychological Association (APA)
Zhao, Shipeng& Chen, Qiang& Kang, Xianwu& Kong, Bin& Wang, Zhuo. 2018. Aberrantly Expressed Genes and miRNAs in Slow Transit Constipation Based on RNA-Seq Analysis. BioMed Research International،Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1125166
Modern Language Association (MLA)
Zhao, Shipeng…[et al.]. Aberrantly Expressed Genes and miRNAs in Slow Transit Constipation Based on RNA-Seq Analysis. BioMed Research International No. 2018 (2018), pp.1-14.
https://search.emarefa.net/detail/BIM-1125166
American Medical Association (AMA)
Zhao, Shipeng& Chen, Qiang& Kang, Xianwu& Kong, Bin& Wang, Zhuo. Aberrantly Expressed Genes and miRNAs in Slow Transit Constipation Based on RNA-Seq Analysis. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1125166
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1125166