Prognostic Nutritional Index and Neutrophil-to-Lymphocyte Ratio Are Respectively Associated with Prognosis of Gastric Cancer with Liver Metatasis Undergoing and without Hepatectomy
Joint Authors
Gao, Jialiang
Wang, Yimin
Li, Fengke
Zhu, Ziyu
Han, Bangling
Wang, Rui
Xie, Rui
Xue, Yingwei
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-10-07
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
To clarify the efficacy of hepatectomy for gastric cancer liver metastasis (GCLM) and to investigate the association between prognostic nutrition index (PNI) or neutrophil-to-lymphocyte ratio (NLR) and prognosis of GCLM undergoing or without hepatectomy.
Methods.
We retrospectively studied 374 patients with GCLM.
The ROC curve was used to determine the optimal cut-off of PNI and NLR.
Patients were divided into groups based on whether hepatectomy was performed, and survival analysis was conducted before and after grouping.
The overall survival (OS) time and 1, 3, 5-year survival rates were also compared.
Results.
Multivariate analysis of all GCLM patients revealed that hepatectomy (p=0.001) was an independent prognosis factor.
And there were statistical differences in OS and 1, 3, 5-year survival rates (p=0.001 of all) between hepatectomy group and nonhepatectomy group.
Multivariate analysis of GCLM undergoing hepatectomy showed that PNI was an independent prognosis factor (p=0.001).
And there were statistical differences in OS and 1, 3, 5‐year survival rates (p=0.001 p=0.005, p=0.001 and p=0.020, respectively) between high PNI group and low PNI group.
Multivariate analysis of GCLM without hepatectomy showed that NLR was an independent prognosis factor (p=0.001).
And there were statistical differences in OS and 1, 3, 5-year survival rates (p=0.001 p=0.008 p=0.031 and p=0.026, respectively) between low NLR group and high NLR group.
Conclusions.
GCLM has a better prognosis with hepatectomy.
High preoperative PNI is a benign prognostic predictor for patients undergoing hepatectomy.
And high preoperative NLR is an adverse prognostic factor for patients without hepatectomy.
American Psychological Association (APA)
Gao, Jialiang& Wang, Yimin& Li, Fengke& Zhu, Ziyu& Han, Bangling& Wang, Rui…[et al.]. 2019. Prognostic Nutritional Index and Neutrophil-to-Lymphocyte Ratio Are Respectively Associated with Prognosis of Gastric Cancer with Liver Metatasis Undergoing and without Hepatectomy. BioMed Research International،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1125188
Modern Language Association (MLA)
Gao, Jialiang…[et al.]. Prognostic Nutritional Index and Neutrophil-to-Lymphocyte Ratio Are Respectively Associated with Prognosis of Gastric Cancer with Liver Metatasis Undergoing and without Hepatectomy. BioMed Research International No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1125188
American Medical Association (AMA)
Gao, Jialiang& Wang, Yimin& Li, Fengke& Zhu, Ziyu& Han, Bangling& Wang, Rui…[et al.]. Prognostic Nutritional Index and Neutrophil-to-Lymphocyte Ratio Are Respectively Associated with Prognosis of Gastric Cancer with Liver Metatasis Undergoing and without Hepatectomy. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1125188
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1125188