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The Immunoexpression of YAP1 and LATS1 Proteins in Clear Cell Renal Cell Carcinoma: Impact on Patients’ Survival
Joint Authors
Kmieć, Zbigniew
Godlewski, J.
Kiezun, J.
Krazinski, B. E.
Kozielec, Z.
Wierzbicki, P. M.
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-03
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The aim of the study was to determine by immunohistochemistry cellular localization and immunoreactivity levels of YAP1 and LATS1 proteins in paired sections of tumor and unchanged renal tissues of 54 clear cell renal cell carcinoma (ccRCC) patients.
Associations between clinical-pathological and overall survival (OS; median follow-up was 40.6 months) data of patients and YAP1 and LATS1 immunoreactivity were analyzed by uni- and multivariate Cox regression model and log-rank test.
YAP1 immunoreactivity was found in the nuclei of tumor cells in 64.8% of ccRCC patients, whereas only 24.1% of tumors revealed cytoplasmic YAP1 expression.
LATS1 immunoexpression was observed only in the cytoplasm of tumor cells in 59.3% of patients.
LATS1 immunoreactivity in cancer cells negatively correlated with the size of primary tumor.
The overall YAP1 immunoreactivity did not correlate with clinical-pathological data of patients.
However, the subgroup of ccRCC patients who presented with cytoplasmic YAP1 immunoexpression had significantly shorter OS (median = 26.8 months) than patients without cytoplasmic YAP1 expression (median undefined).
Multivariate Cox analysis revealed that increased cytoplasmic YAP1 (HR = 4.53) and decreased LATS1 immunoreactivity levels (HR = 0.90) were associated with worse prognosis, being independent prognostic factors.
These results suggest that YAP1 and LATS1 can be considered as new prognostic factors in ccRCC.
American Psychological Association (APA)
Godlewski, J.& Kiezun, J.& Krazinski, B. E.& Kozielec, Z.& Wierzbicki, P. M.& Kmieć, Zbigniew. 2018. The Immunoexpression of YAP1 and LATS1 Proteins in Clear Cell Renal Cell Carcinoma: Impact on Patients’ Survival. BioMed Research International،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1125190
Modern Language Association (MLA)
Godlewski, J.…[et al.]. The Immunoexpression of YAP1 and LATS1 Proteins in Clear Cell Renal Cell Carcinoma: Impact on Patients’ Survival. BioMed Research International No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1125190
American Medical Association (AMA)
Godlewski, J.& Kiezun, J.& Krazinski, B. E.& Kozielec, Z.& Wierzbicki, P. M.& Kmieć, Zbigniew. The Immunoexpression of YAP1 and LATS1 Proteins in Clear Cell Renal Cell Carcinoma: Impact on Patients’ Survival. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1125190
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1125190