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Short-Term Treatment with Esmolol Reverses Left Ventricular Hypertrophy in Adult Spontaneously Hypertensive Rats via Inhibition of AktNF-κB and NFATc4
Joint Authors
Goukassian, David A.
Sasi, Sharath P.
Quintana-Villamandos, Begoña
Delgado-Baeza, Emilio
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-18
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Our group has previously demonstrated that short-term treatment with esmolol reduces left ventricular hypertrophy (LVH) in spontaneously hypertensive rats (SHRs).
The present study aimed to assess the molecular mechanisms related to this effect.
Fourteen-month-old male SHRs were treated intravenously with saline as vehicle (SHR) or esmolol (SHR-E) (300 μg/kg/min).
Age-matched vehicle-treated male Wistar-Kyoto (WKY) rats served as controls.
After 48 hours of treatment, the hearts were harvested and left ventricular tissue was separated and processed for Western blot analysis to determine the levels of Akt, NF-κB, NFATc4, Creb1, Serca2a, Erk1/2, and Sapk/Jnk.
Biomarkers of oxidative stress, such as catalase, protein carbonyls, total thiols, and total antioxidant capacity were evaluated.
Esmolol reversed the levels of p-NFATc4, p-Akt, and p-NF-κB in SHRs to the phospholevels of these proteins in WKY rats without modifying p-Erk1/2, p-Sapk/Jnk, p-Creb1, or Serca2a in SHR.
Compared with SHR, esmolol increased catalase activity and reduced protein carbonyls without modifying total thiols or total antioxidant capacity.
Short-term treatment with esmolol reverses LVH in aged SHRs by downregulation of Akt/NF-κB and NFATc4 activity.
Esmolol treatment also increases catalase activity and reduces oxidative stress in SHRs with LVH.
American Psychological Association (APA)
Quintana-Villamandos, Begoña& Goukassian, David A.& Sasi, Sharath P.& Delgado-Baeza, Emilio. 2018. Short-Term Treatment with Esmolol Reverses Left Ventricular Hypertrophy in Adult Spontaneously Hypertensive Rats via Inhibition of AktNF-κB and NFATc4. BioMed Research International،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1125228
Modern Language Association (MLA)
Quintana-Villamandos, Begoña…[et al.]. Short-Term Treatment with Esmolol Reverses Left Ventricular Hypertrophy in Adult Spontaneously Hypertensive Rats via Inhibition of AktNF-κB and NFATc4. BioMed Research International No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1125228
American Medical Association (AMA)
Quintana-Villamandos, Begoña& Goukassian, David A.& Sasi, Sharath P.& Delgado-Baeza, Emilio. Short-Term Treatment with Esmolol Reverses Left Ventricular Hypertrophy in Adult Spontaneously Hypertensive Rats via Inhibition of AktNF-κB and NFATc4. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1125228
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1125228