Aerobic Interval Training Regulated SIRT3 Attenuates High-Fat-Diet-Associated Cognitive Dysfunction
Joint Authors
Shi, Zhaoling
Li, Chen
Yin, Yue
Yang, Zheng
Xue, Han
Mu, Nan
Wang, Yishi
Liu, Manling
Ma, Heng
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-22
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Cognitive dysfunction is an important complicated disease in obesity.
Exercise ameliorates obesity and the related cognitive dysfunction.
However, the underlying mechanism is still unclear.
In this study, we investigated whether aerobic interval training (AIT) could attenuate high-fat-diet- (HFD-) associated cognitive dysfunction and the possible mechanism of SIRT3-MnSOD pathway.
C57BL/6 wild-type (WT) mice and SIRT3 knockout (KO) mice were randomized into control (Con) or HFD group with or without AIT training for 6 weeks.
The spatial learning and memory ability were impaired in HFD group compared to the control group.
The levels of mitochondrial protein acetylation were increased in the hippocampus of HFD group.
The acetylation level of antioxidative MnSOD was increased as well.
As a result, the ROS and MDA levels were significantly increased, which leads to the neuron apoptosis in the hippocampus.
SIRT3 deficiency further aggravated HFD-induced cognitive dysfunction and susceptibility to oxidative stress injury.
However, AIT upregulated neuron SIRT3 expression and decreased the acetylation of MnSOD.
The hippocampus neuron oxidative stress and apoptosis were both decreased compared to untrained HFD group, which finally improved cognitive function of HFD mice.
Collectively, AIT attenuates HFD-associated cognitive dysfunction through SIRT3 upregulation and improvement of antioxidative MnSOD activity.
American Psychological Association (APA)
Shi, Zhaoling& Li, Chen& Yin, Yue& Yang, Zheng& Xue, Han& Mu, Nan…[et al.]. 2018. Aerobic Interval Training Regulated SIRT3 Attenuates High-Fat-Diet-Associated Cognitive Dysfunction. BioMed Research International،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1125246
Modern Language Association (MLA)
Shi, Zhaoling…[et al.]. Aerobic Interval Training Regulated SIRT3 Attenuates High-Fat-Diet-Associated Cognitive Dysfunction. BioMed Research International No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1125246
American Medical Association (AMA)
Shi, Zhaoling& Li, Chen& Yin, Yue& Yang, Zheng& Xue, Han& Mu, Nan…[et al.]. Aerobic Interval Training Regulated SIRT3 Attenuates High-Fat-Diet-Associated Cognitive Dysfunction. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1125246
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1125246