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Carnosine Protects Mouse Podocytes from High Glucose Induced Apoptosis through PI3KAKT and Nrf2 Pathways
Joint Authors
Zhao, Kunxiao
Li, Ying
Wang, Ziqiang
Han, Ning
Wang, Ying
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-05-28
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Diabetic nephropathy is the complication of diabetes mellitus that can lead to chronic renal failure.
Reactive oxygen species (ROS) production plays an important role in its pathological process.
Previous studies showed that carnosine may reduce diabetic nephropathy by antioxidant effect.
However, the molecular mechanism of its antioxidant was not fully understood.
In the current study, we developed high glucose containing different concentrations of carnosine to reduce ROS levels and podocytes apoptosis, and Cell Counting Kit-8 test was used to observe the cell viability.
Carnosine (5-20mM) was found to protect mouse podocytes (MPC5) cells from HG-induced injury.
Quantitative real-time PCR, Western blotting, and immunofluorescence staining revealed that high glucose induced ROS levels and podocytes apoptosis were downregulated by PI3K/AKT and Nrf2 signaling pathways.
The current findings suggest that carnosine may reduce ROS levels and MPC5 cells apoptosis by PI3K/AKT and Nrf2 signaling pathways activation.
American Psychological Association (APA)
Zhao, Kunxiao& Li, Ying& Wang, Ziqiang& Han, Ning& Wang, Ying. 2019. Carnosine Protects Mouse Podocytes from High Glucose Induced Apoptosis through PI3KAKT and Nrf2 Pathways. BioMed Research International،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1125285
Modern Language Association (MLA)
Zhao, Kunxiao…[et al.]. Carnosine Protects Mouse Podocytes from High Glucose Induced Apoptosis through PI3KAKT and Nrf2 Pathways. BioMed Research International No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1125285
American Medical Association (AMA)
Zhao, Kunxiao& Li, Ying& Wang, Ziqiang& Han, Ning& Wang, Ying. Carnosine Protects Mouse Podocytes from High Glucose Induced Apoptosis through PI3KAKT and Nrf2 Pathways. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1125285
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1125285