Cardiac Magnetic Resonance in Stable Coronary Artery Disease: Added Prognostic Value to Conventional Risk Profiling
Joint Authors
Catalano, Oronzo
Moro, Guido
Mori, Alessia
Perotti, Mariarosa
Gualco, Alessandra
Frascaroli, Mauro
Pesarin, Clara
Napolitano, Carlo
Ntusi, Ntobeko A. B.
Priori, Silvia G.
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-21
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Aims.
Cardiovascular magnetic resonance (CMR) permits a comprehensive evaluation of stable coronary artery disease (CAD).
We sought to assess whether, in a large contemporaneous population receiving optimal medical therapy, CMR independently predicts prognosis beyond conventional cardiovascular risk factors (RF).
Methods.
We performed a single centre, observational prospective study that enrolled 465 CAD patients (80% males; 63±11 years), optimally treated with ACE-inhibitors/ARB, aspirin, and statins (76-85%).
Assessments included conventional evaluation (clinical history, atherosclerosis RF, electrocardiography, and echocardiography) and a comprehensive CMR with LV dimensions/function, late gadolinium enhancement (LGE), and stress perfusion CMR (SPCMR).
Results.
During a median follow-up of 62 months (IQR 23-74) there were 50 deaths and 92 major adverse cardiovascular events (MACE).
CMR variables improved multivariate model prediction power of mortality and MACE over traditional RF alone (F-test p<0.05 and p<0.001, respectively).
LGE was an independent prognostic factor of mortality (hazard ratio [95% CI]: 3.4 [1.3−8.8]); moreover, LGE (3.3 [1.7−6.3]) and SPCMR (2.1 [1.4−3.2]) were the best predictors of MACE.
Conclusion.
LGE is an independent noninvasive marker of mortality in the long term in patients with stable CAD and optimized medical therapy.
Furthermore, LGE and SPCMR independently predict MACE beyond conventional risk stratification.
American Psychological Association (APA)
Catalano, Oronzo& Moro, Guido& Mori, Alessia& Perotti, Mariarosa& Gualco, Alessandra& Frascaroli, Mauro…[et al.]. 2018. Cardiac Magnetic Resonance in Stable Coronary Artery Disease: Added Prognostic Value to Conventional Risk Profiling. BioMed Research International،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1125355
Modern Language Association (MLA)
Catalano, Oronzo…[et al.]. Cardiac Magnetic Resonance in Stable Coronary Artery Disease: Added Prognostic Value to Conventional Risk Profiling. BioMed Research International No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1125355
American Medical Association (AMA)
Catalano, Oronzo& Moro, Guido& Mori, Alessia& Perotti, Mariarosa& Gualco, Alessandra& Frascaroli, Mauro…[et al.]. Cardiac Magnetic Resonance in Stable Coronary Artery Disease: Added Prognostic Value to Conventional Risk Profiling. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1125355
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1125355