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Erythropoiesis and Iron Homeostasis in Non-Transfusion-Dependent Thalassemia Patients with Extramedullary Hematopoiesis
Joint Authors
Huang, Yumei
Liu, Rongrong
Wei, Xiaoyun
Liu, Jiaodi
Pan, Lingyuan
Yang, Gaohui
Lai, Yongrong
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-30
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Extramedullary hematopoiesis (EMH) is common in non-transfusion-dependent thalassemia (NTDT) patients.
Clinical presentations of EMH vary as MRI screening is not feasible.
Hence, serum biomarkers are used to predict the risk of EMH.
Materials and Methods.
52 NTDT patients, including 26 EMH (+) and 26 EMH (-), together with 26 healthy controls, were enrolled in this case-control study from 2013 to 2016.
EMH was confirmed by computed tomography or MRI.
Demographic, transfusion, genetic, laboratory, and liver iron concentration (LIC) data, as well as clinical complications, were analyzed.
Results.
EMH (+) patients had significantly higher serum ferritin (SF), growth differentiation factor 15 (GDF15), and erythropoietin (EPO) levels compared with EMH (-) patients and controls.
The levels of erythroferrone (ERFE), hepcidin, and sTfR did not differ significantly between EMH (+) and EMH (-) patients (p>0.05).
In NTDT patients, serum ERFE was not related to SF, LIC, hepcidin, sTfR, EPO, GDF15, and Hb levels.
GDF15, EPO concentrations, and GDF15 to sTfR and GDF15 to EPO ratios are able to determine the presence of EMH with considerable sensitivity and specificity.
Conclusions.
GDF15, EPO, and GDF15 to EPO and GDF15 to sTfR ratios are potential biomarkers for the early prediction of NTDT in patients who are at risk for EMH.
American Psychological Association (APA)
Huang, Yumei& Liu, Rongrong& Wei, Xiaoyun& Liu, Jiaodi& Pan, Lingyuan& Yang, Gaohui…[et al.]. 2019. Erythropoiesis and Iron Homeostasis in Non-Transfusion-Dependent Thalassemia Patients with Extramedullary Hematopoiesis. BioMed Research International،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1125359
Modern Language Association (MLA)
Huang, Yumei…[et al.]. Erythropoiesis and Iron Homeostasis in Non-Transfusion-Dependent Thalassemia Patients with Extramedullary Hematopoiesis. BioMed Research International No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1125359
American Medical Association (AMA)
Huang, Yumei& Liu, Rongrong& Wei, Xiaoyun& Liu, Jiaodi& Pan, Lingyuan& Yang, Gaohui…[et al.]. Erythropoiesis and Iron Homeostasis in Non-Transfusion-Dependent Thalassemia Patients with Extramedullary Hematopoiesis. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1125359
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1125359