Recent Updates in Pharmacological Properties of Chitooligosaccharides
Joint Authors
Marmouzi, Ilias
Ezzat, Shahira M.
Salama, Maha M.
Merghany, Rana M.
Attar, Aisha M.
EL-Desoky, Ahmed M.
Mohamed, Shanaz O.
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-10-31
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Chemical structures derived from marine foods are highly diverse and pharmacologically promising.
In particular, chitooligosaccharides (COS) present a safe pharmacokinetic profile and a great source of new bioactive polymers.
This review describes the antioxidant, anti-inflammatory, and antidiabetic properties of COS from recent publications.
Thus, COS constitute an effective agent against oxidative stress, cellular damage, and inflammatory pathogenesis.
The mechanisms of action and targeted therapeutic pathways of COS are summarized and discussed.
COS may act as antioxidants via their radical scavenging activity and by decreasing oxidative stress markers.
The mechanism of COS antidiabetic effect is characterized by an acceleration of pancreatic islets proliferation, an increase in insulin secretion and sensitivity, a reduction of postprandial glucose, and an improvement of glucose uptake.
COS upregulate the GLUT2 and inhibit digestive enzyme and glucose transporters.
Furthermore, they resulted in reduction of gluconeogenesis and promotion of glucose conversion.
On the other hand, the COS decrease inflammatory mediators, suppress the activation of NF-κB, increase the phosphorylation of kinase, and stimulate the proliferation of lymphocytes.
Overall, this review brings evidence from experimental data about protective effect of COS.
American Psychological Association (APA)
Marmouzi, Ilias& Ezzat, Shahira M.& Salama, Maha M.& Merghany, Rana M.& Attar, Aisha M.& EL-Desoky, Ahmed M.…[et al.]. 2019. Recent Updates in Pharmacological Properties of Chitooligosaccharides. BioMed Research International،Vol. 2019, no. 2019, pp.1-16.
https://search.emarefa.net/detail/BIM-1125413
Modern Language Association (MLA)
Marmouzi, Ilias…[et al.]. Recent Updates in Pharmacological Properties of Chitooligosaccharides. BioMed Research International No. 2019 (2019), pp.1-16.
https://search.emarefa.net/detail/BIM-1125413
American Medical Association (AMA)
Marmouzi, Ilias& Ezzat, Shahira M.& Salama, Maha M.& Merghany, Rana M.& Attar, Aisha M.& EL-Desoky, Ahmed M.…[et al.]. Recent Updates in Pharmacological Properties of Chitooligosaccharides. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-16.
https://search.emarefa.net/detail/BIM-1125413
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1125413