HOTAIR Is a Potential Novel Biomarker in Patients with Congenital Heart Diseases
Joint Authors
Jiang, Yu
Mo, Hongdan
Luo, Jing
Zhao, Suhong
Liang, Shuang
Zhang, Maomao
Yuan, Jie
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-07
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objective.
To investigate the expression of HOX transcript antisense RNA (HOTAIR) in cardiac tissues and plasma of patients with congenital heart diseases (CHDs).
Methods.
qRT-PCR was used to detect the expression of HOTAIR in right atrial appendage tissues of 16 patients with CHDs and 14 patients with rheumatic valvular heart diseases (RVHDs), as well as in plasma of 36 normal people and 90 patients with CHDs including 36 cases of ASD, 23 cases of VSD, and 31 cases of PDA.
Besides, the proteins interacting with HOTAIR were obtained from databases.
Results.
The HOTAIR expression in cardiac tissues of CHDs group was significantly higher than that of the RVHDs group (P<0.01).
Compared with the control group, the expression of plasma HOTAIR in the ASD group, the VSD group, and the PDA group was all remarkably upregulated (P<0.01), whereas there was no relationship between HOTAIR and pulmonary arterial hypertension and defects size.
Databases show that HOTAIR is associated with polycomb repressive complex 2 (PRC2) which contributes to heart development.
Conclusion.
The levels of HOTAIR were increased in cardiac tissues and plasma of patients with CHDs.
HOTAIR is a potential novel diagnostic biomarker in patients with CHDs.
American Psychological Association (APA)
Jiang, Yu& Mo, Hongdan& Luo, Jing& Zhao, Suhong& Liang, Shuang& Zhang, Maomao…[et al.]. 2018. HOTAIR Is a Potential Novel Biomarker in Patients with Congenital Heart Diseases. BioMed Research International،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1125419
Modern Language Association (MLA)
Jiang, Yu…[et al.]. HOTAIR Is a Potential Novel Biomarker in Patients with Congenital Heart Diseases. BioMed Research International No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1125419
American Medical Association (AMA)
Jiang, Yu& Mo, Hongdan& Luo, Jing& Zhao, Suhong& Liang, Shuang& Zhang, Maomao…[et al.]. HOTAIR Is a Potential Novel Biomarker in Patients with Congenital Heart Diseases. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1125419
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1125419