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Intraoperative Hepatic Blood Inflow Can Predict Early Acute Kidney Injury following DCD Liver Transplantation: A Retrospective Observational Study
Joint Authors
Zhang, Chengshuo
Zhang, Jialin
Jiao, Ao
Sun, Ning
Liu, Qingpeng
Li, Feng
Guo, Rui
Wang, Bowen
Lu, Xianliang
Li, Xiaohang
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-08-06
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Purpose.
Acute kidney injury (AKI) is a major and severe complication following donation-after-circulatory-death (DCD) liver transplantation (LT) and is associated with increased postoperative morbidity and mortality.
However, the risk factors and the prognosis factors of AKI still need to be further explored, and the relativity of intraoperative hepatic blood inflow (HBI) and AKI following LT has not been discussed yet.
The purpose of this study was to investigate the correlation between HBI and AKI and to construct a prediction model of early acute kidney injury (EAKI) following DCD LT with the combination of HBI and other clinical parameters.
Methods.
Clinical data of 132 patients who underwent DCD liver transplantation at the first hospital of China Medical University from April 2005 to March 2017 were analyzed.
Data of 105 patients (the first ten years of patients) were used to develop the prediction model.
Then we assessed the clinical usefulness of the prediction models in the validation cohort (27 patients).
EAKI according to Kidney Disease Improving Global Outcomes (KDIGO) criteria based on serum creatinine increase during 7-day of postoperative follow-up.
Results.
After Least Absolute Shrinkage and Selection Operator (LASSO) regression and simplification, a simplified prediction model consisting of the Child-Turcotte-Pugh (CTP) score (p=0.033), anhepatic phase (p=0.014), packed red blood cell (pRBC) transfusion (p=0.027), and the HBI indexed by height (HBI/h) (p=0.002) was established.
The C-indexes of the model in the development and validation cohort were 0.823 [95% CI, 0.738-0.908] and 0.921 [95% CI, 0.816-1.000], respectively.
Conclusions.
In this study, we demonstrated the utility of HBI/h as a predictor for EAKI following DCD LT, as well as the clinical usefulness of the prediction model through the combination of the CTP score, anhepatic phase, pRBC transfusion and HBI/h.
American Psychological Association (APA)
Jiao, Ao& Liu, Qingpeng& Li, Feng& Guo, Rui& Wang, Bowen& Lu, Xianliang…[et al.]. 2019. Intraoperative Hepatic Blood Inflow Can Predict Early Acute Kidney Injury following DCD Liver Transplantation: A Retrospective Observational Study. BioMed Research International،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1125424
Modern Language Association (MLA)
Jiao, Ao…[et al.]. Intraoperative Hepatic Blood Inflow Can Predict Early Acute Kidney Injury following DCD Liver Transplantation: A Retrospective Observational Study. BioMed Research International No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1125424
American Medical Association (AMA)
Jiao, Ao& Liu, Qingpeng& Li, Feng& Guo, Rui& Wang, Bowen& Lu, Xianliang…[et al.]. Intraoperative Hepatic Blood Inflow Can Predict Early Acute Kidney Injury following DCD Liver Transplantation: A Retrospective Observational Study. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1125424
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1125424