Neuroprotection in Glaucoma: Old and New Promising Treatments
Joint Authors
Pescosolido, Nicola
Mutolo, M. G.
Librando, Aloisa
Rusciano, Dario
Giannotti, Rossella
Pezzino, Salvatore
Source
Advances in Pharmacological and Pharmaceutical Sciences
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-17
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
Glaucoma is a major global cause of blindness, but the molecular mechanisms responsible for the neurodegenerative damage are not clear.
Undoubtedly, the high intraocular pressure (IOP) and the secondary ischemic and mechanical damage of the optic nerve have a crucial role in retinal ganglion cell (RGC) death.
Several studies specifically analyzed the events that lead to nerve fiber layer thinning, showing the importance of both intra- and extracellular factors.
In parallel, many neuroprotective substances have been tested for their efficacy and safety in hindering the negative effects that lead to RGC death.
New formulations of these compounds, also suitable for chronic oral administration, are likely to be used in clinical practice in the future along with conventional therapies, in order to control the progression of the visual impairment due to primary open-angle glaucoma (POAG).
This review illustrates some of these old and new promising agents for the adjuvant treatment of POAG, with particular emphasis on forskolin and melatonin.
American Psychological Association (APA)
Rusciano, Dario& Pezzino, Salvatore& Mutolo, M. G.& Giannotti, Rossella& Librando, Aloisa& Pescosolido, Nicola. 2017. Neuroprotection in Glaucoma: Old and New Promising Treatments. Advances in Pharmacological and Pharmaceutical Sciences،Vol. 2017, no. 2017, pp.1-19.
https://search.emarefa.net/detail/BIM-1125425
Modern Language Association (MLA)
Rusciano, Dario…[et al.]. Neuroprotection in Glaucoma: Old and New Promising Treatments. Advances in Pharmacological and Pharmaceutical Sciences No. 2017 (2017), pp.1-19.
https://search.emarefa.net/detail/BIM-1125425
American Medical Association (AMA)
Rusciano, Dario& Pezzino, Salvatore& Mutolo, M. G.& Giannotti, Rossella& Librando, Aloisa& Pescosolido, Nicola. Neuroprotection in Glaucoma: Old and New Promising Treatments. Advances in Pharmacological and Pharmaceutical Sciences. 2017. Vol. 2017, no. 2017, pp.1-19.
https://search.emarefa.net/detail/BIM-1125425
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1125425