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Effect of Semelil, an Herbal Selenium-Based Medicine, on New Bone Formation in Calvarium of Rabbits
Joint Authors
Abdollahi, Mohammad
Mashhadiabbas, Fatemeh
Rasouli-Ghahroudi, Amir Alireza
Rokn, Amirreza
Yaghobee, Siamak
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-26
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
This study aims to analyze the effect of Semelil, an herbal selenium-based medicine, on osteogenesis in rabbit calvarium defects.
Methods.
Four identical bony defects (8 mm) were created in the calvarium of 16 New Zealand male rabbits and filled randomly with xenogenic bone substitute material (Bio-Oss®) and semelil herbal drug (ANGIPARS™).
One site was filled with Bio-Oss (B); the second site was treated with ANGIPARS (A); the third site was treated with ANGIPARS + Bio-Oss (AB); and the fourth site was left as untreated control (C) and defects were left unfilled.
Rabbits were randomly divided into two groups (n=8) and sacrificed at four and eight weeks.
Percentage of new bone formation, type of the newly formed bone, percentage of the remaining xenograft biomaterial, and foreign body reaction (FBR) were evaluated via histological and histomorphometric analyses.
Results.
The percentage of new bone formation was significantly different among four groups.
The highest effect was observed in AB, followed by A, B, and C groups, respectively.
The difference in the mean percentage of new bone formation between four and eight weeks was significant for all four groups (P<0.001).
Regarding bone formation, the interaction effect of A and B was significant at four (P<0.001) and eight weeks (P=0.002).
ANGIPARS alone and in presence of Bio-Oss enhanced new bone formation at both four and eight weeks (P<0.001).
The mean amount of new bone formation was significantly different at four and eight weeks in groups C (P=0.008), A (P<0.001), B (P<0.001), and AB (P=0.003).
FBR was not observed in any group.
Conclusion.
Semelil may be useful as an adjunct to conventional osteoconductive materials in order to enhance osteogenesis.
American Psychological Association (APA)
Rasouli-Ghahroudi, Amir Alireza& Rokn, Amirreza& Abdollahi, Mohammad& Mashhadiabbas, Fatemeh& Yaghobee, Siamak. 2018. Effect of Semelil, an Herbal Selenium-Based Medicine, on New Bone Formation in Calvarium of Rabbits. BioMed Research International،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1125430
Modern Language Association (MLA)
Rasouli-Ghahroudi, Amir Alireza…[et al.]. Effect of Semelil, an Herbal Selenium-Based Medicine, on New Bone Formation in Calvarium of Rabbits. BioMed Research International No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1125430
American Medical Association (AMA)
Rasouli-Ghahroudi, Amir Alireza& Rokn, Amirreza& Abdollahi, Mohammad& Mashhadiabbas, Fatemeh& Yaghobee, Siamak. Effect of Semelil, an Herbal Selenium-Based Medicine, on New Bone Formation in Calvarium of Rabbits. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1125430
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1125430