Exosomes in Severe Asthma: Update in Their Roles and Potential in Therapy
Joint Authors
Adcock, Ian M.
Alipoor, Shamila D.
Mumby, Sharon
Garssen, J.
Varahram, Mohammad
Jamaati, Hamidreza
Mortaz, Esmaeil
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-08
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Exosomes are nanosized vesicles and have recently been recognized as important players in cell-to-cell communication.
Exosomes contain different mediators such as proteins, nucleic acids (DNA, mRNA, miRNAs, and other ncRNAs), and lipid mediators and can shuttle their exosomal content to both neighboring and distal cells.
Exosomes are very effective in orchestrating immune responses in the airways and all cell types can contribute to the systemic exosome pool.
Intracellular communication between the broad range of cell types within the lung is crucial in disease emphasizing the importance of exosomes.
In asthma, exosomes affect the inflammatory microenvironment which ultimately determines the development or alleviation of the pathological symptoms.
Recent studies in this area have provided insight into the underlying mechanisms of disease and led to interest in using exosomes as potential novel therapeutic agents.
American Psychological Association (APA)
Mortaz, Esmaeil& Alipoor, Shamila D.& Varahram, Mohammad& Jamaati, Hamidreza& Garssen, J.& Mumby, Sharon…[et al.]. 2018. Exosomes in Severe Asthma: Update in Their Roles and Potential in Therapy. BioMed Research International،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1125438
Modern Language Association (MLA)
Mortaz, Esmaeil…[et al.]. Exosomes in Severe Asthma: Update in Their Roles and Potential in Therapy. BioMed Research International No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1125438
American Medical Association (AMA)
Mortaz, Esmaeil& Alipoor, Shamila D.& Varahram, Mohammad& Jamaati, Hamidreza& Garssen, J.& Mumby, Sharon…[et al.]. Exosomes in Severe Asthma: Update in Their Roles and Potential in Therapy. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1125438
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1125438