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Investigation of the Clinical Significance and Prognostic Value of the lncRNA ACVR2B-As1 in Liver Cancer
Joint Authors
Nie, Yuanyuan
Jiao, Yan
Li, Yanqing
Li, Wei
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-10-30
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
A refined liver cancer staging system and effective prognostic prediction can help clinicians make optimized treatment decisions, which is essential in our fight against cancer and for improving the unsatisfying survival rate of liver cancer globally.
The prognosis of liver cancer is not only related to tumor status, it is also affected by the patients’ liver functions and the chosen treatment.
Currently, several staging systems are being tested.
Herein, we analyzed RNA-seq data from the TCGA database and identified a newly annotated lncRNA, ACVR2B-AS1, whose expression is upregulated in liver cancer.
Higher ACVR2B-AS1 expression is an independent adverse prognostic factor for overall survival (OS) and relapse-free survival (RFS) in liver cancer patients.
Our work suggests that the lncRNA ACVR2B-AS1 could be a candidate biomarker for liver cancer prognosis.
Furthermore, ACVR2B-AS1 might serve as a potential therapeutic target, which is a possibility that is worthy of further study.
American Psychological Association (APA)
Nie, Yuanyuan& Jiao, Yan& Li, Yanqing& Li, Wei. 2019. Investigation of the Clinical Significance and Prognostic Value of the lncRNA ACVR2B-As1 in Liver Cancer. BioMed Research International،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1125443
Modern Language Association (MLA)
Nie, Yuanyuan…[et al.]. Investigation of the Clinical Significance and Prognostic Value of the lncRNA ACVR2B-As1 in Liver Cancer. BioMed Research International No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1125443
American Medical Association (AMA)
Nie, Yuanyuan& Jiao, Yan& Li, Yanqing& Li, Wei. Investigation of the Clinical Significance and Prognostic Value of the lncRNA ACVR2B-As1 in Liver Cancer. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1125443
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1125443