miR-34a Inhibits Cell Proliferation by Targeting SATB2 in Hepatocellular Carcinoma
Joint Authors
Wu, Gang
Li, Zhixi
Wang, Youyu
Ju, Xueming
Huang, Rui
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-06
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Hepatocellular carcinoma (HCC) is the most common type of malignancy of the liver and has been reported as the third most frequent cause of cancer associated death worldwide.
Accumulating evidence showed that the expression of miR-34a was abnormal in HCC patients; however, the role of miR-34a in HCC is not clear.
In this study, we have observed low expression of the miR-34a in both HCC tissues and hepatoma cell line as compared to normal control.
Further to investigate the role of miR-34a in HCC development, HepG2 cells were transfected with miR-34a mimic.
Following transfection, miR-34a expression was significantly increased, which further repressed proliferation of HepG2 cells.
Bioinformatics, Luciferase Reporter, RT-qPCR, and western blotting assays indicated that special AT-rich sequence-binding protein-2 (SATB2) is a direct target of miR-34a in HCC cells.
There was a negative correlation between the expression levels of SATB2 and miR-34a.
Investigation into the molecular mechanism indicated that miR-34a regulated cell proliferation through inhibiting SATB2.
Therefore, the results of the present study may improve understanding regarding the role of miR-34a in regulating cell proliferation and contribute to the development of novel therapy of HCC.
American Psychological Association (APA)
Wu, Gang& Li, Zhixi& Wang, Youyu& Ju, Xueming& Huang, Rui. 2018. miR-34a Inhibits Cell Proliferation by Targeting SATB2 in Hepatocellular Carcinoma. BioMed Research International،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1125450
Modern Language Association (MLA)
Wu, Gang…[et al.]. miR-34a Inhibits Cell Proliferation by Targeting SATB2 in Hepatocellular Carcinoma. BioMed Research International No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1125450
American Medical Association (AMA)
Wu, Gang& Li, Zhixi& Wang, Youyu& Ju, Xueming& Huang, Rui. miR-34a Inhibits Cell Proliferation by Targeting SATB2 in Hepatocellular Carcinoma. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1125450
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1125450