A Systematic Review of Potential Therapeutic Use of Lycium Barbarum Polysaccharides in Disease
Joint Authors
Lai, Jimmy S. M.
So, Kwok-fai
Chan, Tommy C. Y.
Kwok, Sum Sum
Bu, Yashan
Shih, Kendrick Co
Lo, Amy Cheuk Yin
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-12
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Objective.
To evaluate the effect of Lycium barbarum polysaccharides in the treatment and/or prevention of diseases of different etiologies and systems.
Methods.
We performed an Entrez PubMed literature search using keywords “lycium”, “barbarum”, “polysaccharides”, “anti-fibrotic”, “anti-apoptotic”, “anti-oxidizing”, “anti-aging”, “neuroprotection”, “metabolism”, “diabetes”, “hyperlipidemia”, “neuroprotection”, and “immunomodulation” on the 14th of August 2018, resulting in 207 papers, of which 20 were chosen after filtering for ‘English language’ and ‘published within 10 years’ as well as curation for relevance by the authors.
Results.
The 20 selected papers included 2 randomized control trials (1 double-blinded RCT and 1 double-blinded placebo-controlled RCT), 11 in vivo studies, 5 in vitro studies, 1 study with both in vivo and in vitro results, and 1 chemical study.
There is good evidence from existing studies on the antifibrotic, antioxidizing, neuroprotective, anticancer, and anti-inflammatory effects of Lycium barbarum polysaccharides.
However, there is a need for further studies in the form of large-scale clinical trials to support its use in humans.
There is also significant potential for LBP as a safe and effective topical treatment in ocular surface diseases, owing to promising in vitro results and a lack of demonstrated toxic effects to corneal epithelial cells.
Conclusion.
Results from existing studies suggest that LBP is a promising therapeutic agent, particularly in the management of liver disease, hyperlipidemia, and diabetes.
One major limitation of current research is a lack of standardization and quality control for the LBP used.
The availability of research-grade LBP will inevitably promote future research in this field worldwide.
American Psychological Association (APA)
Kwok, Sum Sum& Bu, Yashan& Lo, Amy Cheuk Yin& Chan, Tommy C. Y.& So, Kwok-fai& Lai, Jimmy S. M.…[et al.]. 2019. A Systematic Review of Potential Therapeutic Use of Lycium Barbarum Polysaccharides in Disease. BioMed Research International،Vol. 2019, no. 2019, pp.1-18.
https://search.emarefa.net/detail/BIM-1125456
Modern Language Association (MLA)
Kwok, Sum Sum…[et al.]. A Systematic Review of Potential Therapeutic Use of Lycium Barbarum Polysaccharides in Disease. BioMed Research International No. 2019 (2019), pp.1-18.
https://search.emarefa.net/detail/BIM-1125456
American Medical Association (AMA)
Kwok, Sum Sum& Bu, Yashan& Lo, Amy Cheuk Yin& Chan, Tommy C. Y.& So, Kwok-fai& Lai, Jimmy S. M.…[et al.]. A Systematic Review of Potential Therapeutic Use of Lycium Barbarum Polysaccharides in Disease. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-18.
https://search.emarefa.net/detail/BIM-1125456
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1125456