A Novel Scoring System Based on the Level of HDL-C for Predicting the Prognosis of t-DLBCL Patients: A Single Retrospective Study
Joint Authors
Xu, Jiadai
Wei, Zheng
Zhang, Yian
Chen, Chen
Li, Jing
Liu, Peng
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-30
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The t-DLBCL patients are generally regarded to experience a poor prognosis.
However, there is little consensus to guide optimal management strategies for such patients group.
The present study aimed to explore the incidence of transformation and the prognosis factors for t-DLBCL patients, thereby providing insights for clinical choices.
We retrospectively investigated 46 patients with diffuse large B-cell lymphomas (DLBCL) associated with an indolent small B-cell non-Hodgkin lymphoma (iNHL) from January 2007 to June 2017 in our department.
In multivariate analysis, bone marrow (BM) involvement and low level of high-density lipoprotein cholesterol (HDL-C) were considered as two negatively and independently prognostic factors for overall survival (OS) (BM: p=0.007, HR 7.475, 95%CI: 1.744-32.028; HDL-C: p=0.032, HR10.037, 95%CI: 1.226-82.162).
International Prognostic Index (IPI) risk group was identified as a single independent prognostic factor of progression-free survival (PFS) (p=0.048, HR 2.895, 95%CI: 1.010-8.297).
A novel prognostic scoring system named BH model (BH stands for the intertwined initials of BM situation and the level of HDL-C) was further developed to stratify these patients into two risk groups, which performed well.
Combining the BH scoring model and IPI scoring system could better predict the outcomes of these patients.
American Psychological Association (APA)
Xu, Jiadai& Wei, Zheng& Zhang, Yian& Chen, Chen& Li, Jing& Liu, Peng. 2018. A Novel Scoring System Based on the Level of HDL-C for Predicting the Prognosis of t-DLBCL Patients: A Single Retrospective Study. BioMed Research International،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1125471
Modern Language Association (MLA)
Xu, Jiadai…[et al.]. A Novel Scoring System Based on the Level of HDL-C for Predicting the Prognosis of t-DLBCL Patients: A Single Retrospective Study. BioMed Research International No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1125471
American Medical Association (AMA)
Xu, Jiadai& Wei, Zheng& Zhang, Yian& Chen, Chen& Li, Jing& Liu, Peng. A Novel Scoring System Based on the Level of HDL-C for Predicting the Prognosis of t-DLBCL Patients: A Single Retrospective Study. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1125471
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1125471