Increased Sulfiredoxin Expression in Gastric Cancer Cells May Be a Molecular Target of the Anticancer Component Diallyl Trisulfide
Joint Authors
Wang, Juan
Si, Ligang
Wang, Genyu
Bai, Zhigang
Li, Wenmei
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Sulfiredoxin (Srx) is a newly discovered antioxidant enzyme playing a role in the catalytic reduction of oxidative modifications.
Srx is overexpressed in a variety of cancers.
It may promote carcinogenesis as well as tumor progression.
In this study, we report for the first time that Srx expression might be positively associated with the development of gastric cancer and tumor malignancy.
Immunohistochemistry showed that, compared to normal tissues (42%, 20/47), Srx expression in gastric tumors (85%, 40/47) was much more common (chi-square test, p<0.01).
In addition, the staining of Srx was stronger in poorly differentiated gastric cancer than in well-differentiated gastric cancer.
Western blotting showed that, in the gastric tumor cell line BGC823, the Srx protein was upregulated in response to H2O2 treatment, although it was inadequate to counteract the increased oxidative stress, as indicated by the gradually increasing level of malondialdehyde (MDA).
In addition, Srx expression, MDA levels, and ROS levels in BGC823 cells were markedly inhibited upon treatment with diallyl trisulfide (DATS), a major constituent of garlic oil with proven anticancer effects.
These results suggest that Srx may be an oxidative stress marker.
Antioxidation may account for the anticancer potential of garlic.
American Psychological Association (APA)
Wang, Juan& Si, Ligang& Wang, Genyu& Bai, Zhigang& Li, Wenmei. 2019. Increased Sulfiredoxin Expression in Gastric Cancer Cells May Be a Molecular Target of the Anticancer Component Diallyl Trisulfide. BioMed Research International،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1125475
Modern Language Association (MLA)
Wang, Juan…[et al.]. Increased Sulfiredoxin Expression in Gastric Cancer Cells May Be a Molecular Target of the Anticancer Component Diallyl Trisulfide. BioMed Research International No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1125475
American Medical Association (AMA)
Wang, Juan& Si, Ligang& Wang, Genyu& Bai, Zhigang& Li, Wenmei. Increased Sulfiredoxin Expression in Gastric Cancer Cells May Be a Molecular Target of the Anticancer Component Diallyl Trisulfide. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1125475
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1125475