Pregabalin Effect on Acute and Chronic Pain after Cardiac Surgery
Joint Authors
Karanikolas, Menelaos
Petsiti, Argyro
Tassoudis, Vassilios
Bouzia, Aik
Tsilimingas, Nikolaos
Arnaoutoglou, Elena
Vretzakis, George
Source
Anesthesiology Research and Practice
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-04-30
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Introduction.
Pain after cardiac surgery affects long-term patient wellness.
This study investigated the effect of preoperative pregabalin on acute and chronic pain after elective cardiac surgery with median sternotomy.
Methods.
Prospective double blind study.
93 cardiac surgery patients were randomly assigned into three groups: Group 1 received placebo, Group 2 received oral pregabalin 75 mg, and Group 3 received oral pregabalin 150 mg.
Data were collected 8 hours, 24 hours, and 3 months postoperatively.
Results.
Patients receiving pregabalin required fewer morphine boluses (10 in controls versus 6 in Group 1 versus 4 in Group 2, p=0.000) and had lower pain scores at 8 hours (4 versus 3 versus 3, p=0.001) and 3 months (3 versus 2 versus 2, p=0.000) and lower morphine consumption at 8 hours (14 versus 13 versus 12 mg, p=0.000) and 24 hours (19.5 versus 16 versus 15 mg, p=0.000).
Percentage of patients with sleep disturbances or requiring analgesics was lower in the pregabalin group and even lower with higher pregabalin dose (16/31 versus 5/31 versus 3/31, p=0.000, and 26/31 versus 16/31 versus 10/31, p=0.000, resp.) 3 months after surgery.
Conclusion.
Preoperative oral pregabalin 75 or 150 mg reduces postoperative morphine requirements and acute and chronic pain after cardiac surgery.
American Psychological Association (APA)
Bouzia, Aik& Tassoudis, Vassilios& Karanikolas, Menelaos& Vretzakis, George& Petsiti, Argyro& Tsilimingas, Nikolaos…[et al.]. 2017. Pregabalin Effect on Acute and Chronic Pain after Cardiac Surgery. Anesthesiology Research and Practice،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1125494
Modern Language Association (MLA)
Bouzia, Aik…[et al.]. Pregabalin Effect on Acute and Chronic Pain after Cardiac Surgery. Anesthesiology Research and Practice No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1125494
American Medical Association (AMA)
Bouzia, Aik& Tassoudis, Vassilios& Karanikolas, Menelaos& Vretzakis, George& Petsiti, Argyro& Tsilimingas, Nikolaos…[et al.]. Pregabalin Effect on Acute and Chronic Pain after Cardiac Surgery. Anesthesiology Research and Practice. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1125494
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1125494