A Risk Stratification Model for Lung Cancer Based on Gene Coexpression Network and Deep Learning
Joint Authors
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-16
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Risk stratification model for lung cancer with gene expression profile is of great interest.
Instead of previous models based on individual prognostic genes, we aimed to develop a novel system-level risk stratification model for lung adenocarcinoma based on gene coexpression network.
Using multiple microarray, gene coexpression network analysis was performed to identify survival-related networks.
A deep learning based risk stratification model was constructed with representative genes of these networks.
The model was validated in two test sets.
Survival analysis was performed using the output of the model to evaluate whether it could predict patients’ survival independent of clinicopathological variables.
Five networks were significantly associated with patients’ survival.
Considering prognostic significance and representativeness, genes of the two survival-related networks were selected for input of the model.
The output of the model was significantly associated with patients’ survival in two test sets and training set (p<0.00001, p<0.0001 and p=0.02 for training and test sets 1 and 2, resp.).
In multivariate analyses, the model was associated with patients’ prognosis independent of other clinicopathological features.
Our study presents a new perspective on incorporating gene coexpression networks into the gene expression signature and clinical application of deep learning in genomic data science for prognosis prediction.
American Psychological Association (APA)
Choi, Hongyoon& Na, Kwon Joong. 2018. A Risk Stratification Model for Lung Cancer Based on Gene Coexpression Network and Deep Learning. BioMed Research International،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1125503
Modern Language Association (MLA)
Choi, Hongyoon& Na, Kwon Joong. A Risk Stratification Model for Lung Cancer Based on Gene Coexpression Network and Deep Learning. BioMed Research International No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1125503
American Medical Association (AMA)
Choi, Hongyoon& Na, Kwon Joong. A Risk Stratification Model for Lung Cancer Based on Gene Coexpression Network and Deep Learning. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1125503
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1125503