Controversies and Misconceptions Related to Cerebrospinal Fluid Circulation: A Review of the Literature from the Historical Pioneers’ Theories to Current Models
Joint Authors
De Bonis, Pasquale
Mantovani, Giorgio
Menegatti, Marta
Scerrati, Alba
Cavallo, Michele Alessandro
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-11-26
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Models of cerebrospinal fluid (CSF) circulation have been mainly proposed in the last century: CSF goes from the ventricles to the subarachnoidal space (SAS), passing through the aqueduct and the foramen of Luschka and Magendie.
Indeed, new models, involving the Virchow-Robin space (VRS) and the perivascular space (PVS), have been proposed.
We critically reviewed the literature, in order to clarify the “classical” errors and to discuss the “new” models that are evolving currently.
Conclusions of past experiments are often not justified, due to lack of reproducibility and methodological issues.
On the other hand, investigation on the microanatomy of Virchow-Robin spaces (VRS) and several new experiments showed a potential pathway for a more complex CSF “circulation,” with chaotic and unpredictable flows.
It seems reasonable to elaborate a new model of CSF physiology, including new findings and questioning old certainties.
However, proved data are still missing and it is hazardous to come to final conclusions.
More studies are needed.
American Psychological Association (APA)
Mantovani, Giorgio& Menegatti, Marta& Scerrati, Alba& Cavallo, Michele Alessandro& De Bonis, Pasquale. 2018. Controversies and Misconceptions Related to Cerebrospinal Fluid Circulation: A Review of the Literature from the Historical Pioneers’ Theories to Current Models. BioMed Research International،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1125512
Modern Language Association (MLA)
Mantovani, Giorgio…[et al.]. Controversies and Misconceptions Related to Cerebrospinal Fluid Circulation: A Review of the Literature from the Historical Pioneers’ Theories to Current Models. BioMed Research International No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1125512
American Medical Association (AMA)
Mantovani, Giorgio& Menegatti, Marta& Scerrati, Alba& Cavallo, Michele Alessandro& De Bonis, Pasquale. Controversies and Misconceptions Related to Cerebrospinal Fluid Circulation: A Review of the Literature from the Historical Pioneers’ Theories to Current Models. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1125512
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1125512