Different Activity Patterns in Retinal Ganglion Cells of TRPM1 and mGluR6 Knockout Mice
Joint Authors
Takeuchi, Haruki
Horie, Sho
Moritoh, Satoru
Matsushima, Hiroki
Hori, Tesshu
Kimori, Yoshitaka
Tsubo, Yasuhiro
Tachibana, Masao
Koike, Chieko
Kitano, K.
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-08
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
TRPM1, the first member of the melanoma-related transient receptor potential (TRPM) subfamily, is the visual transduction channel downstream of metabotropic glutamate receptor 6 (mGluR6) on retinal ON bipolar cells (BCs).
Human TRPM1 mutations are associated with congenital stationary night blindness (CSNB).
In both TRPM1 and mGluR6 KO mouse retinas, OFF but not ON BCs respond to light stimulation.
Here we report an unexpected difference between TRPM1 knockout (KO) and mGluR6 KO mouse retinas.
We used a multielectrode array (MEA) to record spiking in retinal ganglion cells (RGCs).
We found spontaneous oscillations in TRPM1 KO retinas, but not in mGluR6 KO retinas.
We performed a structural analysis on the synaptic terminals of rod ON BCs.
Intriguingly, rod ON BC terminals were significantly smaller in TRPM1 KO retinas than in mGluR6 KO retinas.
These data suggest that a deficiency of TRPM1, but not of mGluR6, in rod ON bipolar cells may affect synaptic terminal maturation.
We speculate that impaired signaling between rod BCs and AII amacrine cells (ACs) leads to spontaneous oscillations.
TRPM1 and mGluR6 are both essential components in the signaling pathway from photoreceptors to ON BC dendrites, yet they differ in their effects on the BC terminal and postsynaptic circuitry.
American Psychological Association (APA)
Takeuchi, Haruki& Horie, Sho& Moritoh, Satoru& Matsushima, Hiroki& Hori, Tesshu& Kimori, Yoshitaka…[et al.]. 2018. Different Activity Patterns in Retinal Ganglion Cells of TRPM1 and mGluR6 Knockout Mice. BioMed Research International،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1125547
Modern Language Association (MLA)
Takeuchi, Haruki…[et al.]. Different Activity Patterns in Retinal Ganglion Cells of TRPM1 and mGluR6 Knockout Mice. BioMed Research International No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1125547
American Medical Association (AMA)
Takeuchi, Haruki& Horie, Sho& Moritoh, Satoru& Matsushima, Hiroki& Hori, Tesshu& Kimori, Yoshitaka…[et al.]. Different Activity Patterns in Retinal Ganglion Cells of TRPM1 and mGluR6 Knockout Mice. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1125547
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1125547