Killing Two Angry Birds with One Stone: Autophagy Activation by Inhibiting Calpains in Neurodegenerative Diseases and Beyond
Joint Authors
Weber, Jonasz Jeremiasz
Pereira Sena, Priscila
Singer, Elisabeth
Nguyen, Huu Phuc
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-14
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Proteolytic machineries execute vital cellular functions and their disturbances are implicated in diverse medical conditions, including neurodegenerative diseases.
Interestingly, calpains, a class of Ca2+-dependent regulatory proteases, can modulate the degradational system of autophagy by cleaving proteins involved in this pathway.
Moreover, both machineries are common players in many molecular pathomechanisms and have been targeted individually or together, as a therapeutic strategy in experimental setups.
In this review, we briefly introduce calpains and autophagy, with their roles in health and disease, and focus on their direct pathologically relevant interplay in neurodegeneration and beyond.
The modulation of calpain activity may comprise a promising treatment approach to attenuate the deregulation of these two essential mechanisms.
American Psychological Association (APA)
Weber, Jonasz Jeremiasz& Pereira Sena, Priscila& Singer, Elisabeth& Nguyen, Huu Phuc. 2019. Killing Two Angry Birds with One Stone: Autophagy Activation by Inhibiting Calpains in Neurodegenerative Diseases and Beyond. BioMed Research International،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1125550
Modern Language Association (MLA)
Weber, Jonasz Jeremiasz…[et al.]. Killing Two Angry Birds with One Stone: Autophagy Activation by Inhibiting Calpains in Neurodegenerative Diseases and Beyond. BioMed Research International No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1125550
American Medical Association (AMA)
Weber, Jonasz Jeremiasz& Pereira Sena, Priscila& Singer, Elisabeth& Nguyen, Huu Phuc. Killing Two Angry Birds with One Stone: Autophagy Activation by Inhibiting Calpains in Neurodegenerative Diseases and Beyond. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1125550
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1125550