Different Subtypes of Influenza Viruses Target Different Human Proteins and Pathways Leading to Different Pathogenic Phenotypes

Joint Authors

Liang, Long
Yue, Junjie
Ren, Hongguang
Wang, Yujie
Song, Ting
Li, Kaiwu
Jin, Yuan

Source

BioMed Research International

Issue

Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2019-10-22

Country of Publication

Egypt

No. of Pages

7

Main Subjects

Medicine

Abstract EN

Different subtypes of influenza A viruses (IAVs) cause different pathogenic phenotypes after infecting human bodies.

Analysis of the interactions between viral proteins and the host proteins may provide insights into the pathogenic mechanisms of the virus.

In this paper, we found that the same proteins (nucleoprotein and neuraminidase) of H1N1 and H5N1 have different impacts on the NF-κB activation.

By further examining the virus–host protein–protein interactions, we found that both NP and NA proteins of the H1N1 and H5N1 viruses target different host proteins.

These results indicate that different subtypes of influenza viruses target different human proteins and pathways leading to different pathogenic phenotypes.

American Psychological Association (APA)

Wang, Yujie& Song, Ting& Li, Kaiwu& Jin, Yuan& Yue, Junjie& Ren, Hongguang…[et al.]. 2019. Different Subtypes of Influenza Viruses Target Different Human Proteins and Pathways Leading to Different Pathogenic Phenotypes. BioMed Research International،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1125600

Modern Language Association (MLA)

Wang, Yujie…[et al.]. Different Subtypes of Influenza Viruses Target Different Human Proteins and Pathways Leading to Different Pathogenic Phenotypes. BioMed Research International No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1125600

American Medical Association (AMA)

Wang, Yujie& Song, Ting& Li, Kaiwu& Jin, Yuan& Yue, Junjie& Ren, Hongguang…[et al.]. Different Subtypes of Influenza Viruses Target Different Human Proteins and Pathways Leading to Different Pathogenic Phenotypes. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1125600

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1125600