Different Subtypes of Influenza Viruses Target Different Human Proteins and Pathways Leading to Different Pathogenic Phenotypes
Joint Authors
Liang, Long
Yue, Junjie
Ren, Hongguang
Wang, Yujie
Song, Ting
Li, Kaiwu
Jin, Yuan
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-10-22
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Different subtypes of influenza A viruses (IAVs) cause different pathogenic phenotypes after infecting human bodies.
Analysis of the interactions between viral proteins and the host proteins may provide insights into the pathogenic mechanisms of the virus.
In this paper, we found that the same proteins (nucleoprotein and neuraminidase) of H1N1 and H5N1 have different impacts on the NF-κB activation.
By further examining the virus–host protein–protein interactions, we found that both NP and NA proteins of the H1N1 and H5N1 viruses target different host proteins.
These results indicate that different subtypes of influenza viruses target different human proteins and pathways leading to different pathogenic phenotypes.
American Psychological Association (APA)
Wang, Yujie& Song, Ting& Li, Kaiwu& Jin, Yuan& Yue, Junjie& Ren, Hongguang…[et al.]. 2019. Different Subtypes of Influenza Viruses Target Different Human Proteins and Pathways Leading to Different Pathogenic Phenotypes. BioMed Research International،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1125600
Modern Language Association (MLA)
Wang, Yujie…[et al.]. Different Subtypes of Influenza Viruses Target Different Human Proteins and Pathways Leading to Different Pathogenic Phenotypes. BioMed Research International No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1125600
American Medical Association (AMA)
Wang, Yujie& Song, Ting& Li, Kaiwu& Jin, Yuan& Yue, Junjie& Ren, Hongguang…[et al.]. Different Subtypes of Influenza Viruses Target Different Human Proteins and Pathways Leading to Different Pathogenic Phenotypes. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1125600
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1125600