Efficacy of Artesunate against Pseudomonas aeruginosa Biofilm Mediated by Iron
Joint Authors
Lu, Qi
Feng, Lei
Bao, Lei
Guo, Jinjin
Zhou, Xianjie
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-11
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Pseudomonas aeruginosa is capable of causing a variety of chronic infections due to the formation of biofilms.
Iron is essential for growth of Pseudomonas aeruginosa, and therapies that interfere with iron may help treat P.
aeruginosa infections.
Herein, we investigated whether artesunate, which is a type of iron-dependent drug, could influence Pseudomonas aeruginosa biofilm formation and structure, including the underlying mechanisms.
Artesunate could enhance twitching motility significantly and decrease the proportion of surviving cells in Pseudomonas aeruginosa biofilms in a dose-dependent manner.
Artesunate treatment also reduced biofilm thickness, diffusion in the biomass, and the content of Fe(II).
However, changes in biofilm structure and ion concentration were very similar following treatment with 512 μg/ml and 1024 μg/ml artesunate.
Interestingly, both biofilm structure and surviving cell fraction were recovered after iron supplementation.
These results suggest that artesunate interferes with Pseudomonas aeruginosa biofilms by decreasing bacterial viability and enhancing twitching motility in an iron-independent manner.
American Psychological Association (APA)
Bao, Lei& Guo, Jinjin& Feng, Lei& Zhou, Xianjie& Lu, Qi. 2019. Efficacy of Artesunate against Pseudomonas aeruginosa Biofilm Mediated by Iron. BioMed Research International،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1125618
Modern Language Association (MLA)
Bao, Lei…[et al.]. Efficacy of Artesunate against Pseudomonas aeruginosa Biofilm Mediated by Iron. BioMed Research International No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1125618
American Medical Association (AMA)
Bao, Lei& Guo, Jinjin& Feng, Lei& Zhou, Xianjie& Lu, Qi. Efficacy of Artesunate against Pseudomonas aeruginosa Biofilm Mediated by Iron. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1125618
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1125618