Neuroinflammatory Cytokines Induce Amyloid Beta Neurotoxicity through Modulating Amyloid Precursor Protein LevelsMetabolism
Joint Authors
Alasmari, Fawaz
Alshammari, Musaad A.
Alasmari, Abdullah F.
Alanazi, Wael A.
Alhazzani, Khalid
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-10-25
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Neuroinflammation has been observed in association with neurodegenerative diseases including Alzheimer’s disease (AD).
In particular, a positive correlation has been documented between neuroinflammatory cytokine release and the progression of the AD, which suggests these cytokines are involved in AD pathophysiology.
A histological hallmark of the AD is the presence of beta-amyloid (Aβ) plaques and tau neurofibrillary tangles.
Beta-amyloid is generated by the sequential cleavage of beta (β) and gamma (γ) sites in the amyloid precursor protein (APP) by β- and γ-secretase enzymes and its accumulation can result from either a decreased Aβ clearance or increased metabolism of APP.
Previous studies reported that neuroinflammatory cytokines reduce the efflux transport of Aβ, leading to elevated Aβ concentrations in the brain.
However, less is known about the effects of neuroinflammatory mediators on APP expression and metabolism.
In this article, we review the modulatory role of neuroinflammatory cytokines on APP expression and metabolism, including their effects on β- and γ-secretase enzymes.
American Psychological Association (APA)
Alasmari, Fawaz& Alshammari, Musaad A.& Alasmari, Abdullah F.& Alanazi, Wael A.& Alhazzani, Khalid. 2018. Neuroinflammatory Cytokines Induce Amyloid Beta Neurotoxicity through Modulating Amyloid Precursor Protein LevelsMetabolism. BioMed Research International،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1125619
Modern Language Association (MLA)
Alasmari, Fawaz…[et al.]. Neuroinflammatory Cytokines Induce Amyloid Beta Neurotoxicity through Modulating Amyloid Precursor Protein LevelsMetabolism. BioMed Research International No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1125619
American Medical Association (AMA)
Alasmari, Fawaz& Alshammari, Musaad A.& Alasmari, Abdullah F.& Alanazi, Wael A.& Alhazzani, Khalid. Neuroinflammatory Cytokines Induce Amyloid Beta Neurotoxicity through Modulating Amyloid Precursor Protein LevelsMetabolism. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1125619
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1125619