Degalactotigonin, a Steroidal Glycoside from Solanum nigrum, Induces Apoptosis and Cell Cycle Arrest via Inhibiting the EGFR Signaling Pathways in Pancreatic Cancer Cells
Joint Authors
Dang, Nguyen Hai
Minh, Chau Van
Do, Thi Thao
Tuan Anh, Hoang Le
Tran, Phuong Thao
Trang, Duong Thu
Van Cuong, Pham
Kiem, Phan Van
Lee, Jeong-Hyung
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-16
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Degalactotigonin (1) and three other steroidal compounds solasodine (2), O-acetyl solasodine (3), and soladulcoside A (4) were isolated from the methanolic extract of Solanum nigrum, and their chemical structures were elucidated by spectroscopic analyses.
The isolated compounds were evaluated for cytotoxic activity against human pancreatic cancer cell lines (PANC1 and MIA-PaCa2) and lung cancer cell lines (A549, NCI-H1975, and NCI-H1299).
Only degalactotigonin (1) showed potent cytotoxicity against these cancer cell lines.
Compound 1 induced apoptosis in PANC1 and A549 cells.
Further study on its mechanism of action in PANC1 cells demonstrated that 1 significantly inhibited EGF-induced proliferation and migration in a concentration-dependent manner.
Treatment of PANC1 cells with degalactotigonin induced cell cycle arrest at G0/G1 phase.
Compound 1 induced downregulation of cyclin D1 and upregulation of p21 in a time- and concentration-dependent manner and inhibited EGF-induced phosphorylation of EGFR, as well as activation of EGFR downstream signaling molecules such as Akt and ERK.
American Psychological Association (APA)
Tuan Anh, Hoang Le& Tran, Phuong Thao& Do, Thi Thao& Trang, Duong Thu& Dang, Nguyen Hai& Van Cuong, Pham…[et al.]. 2018. Degalactotigonin, a Steroidal Glycoside from Solanum nigrum, Induces Apoptosis and Cell Cycle Arrest via Inhibiting the EGFR Signaling Pathways in Pancreatic Cancer Cells. BioMed Research International،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1125646
Modern Language Association (MLA)
Tuan Anh, Hoang Le…[et al.]. Degalactotigonin, a Steroidal Glycoside from Solanum nigrum, Induces Apoptosis and Cell Cycle Arrest via Inhibiting the EGFR Signaling Pathways in Pancreatic Cancer Cells. BioMed Research International No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1125646
American Medical Association (AMA)
Tuan Anh, Hoang Le& Tran, Phuong Thao& Do, Thi Thao& Trang, Duong Thu& Dang, Nguyen Hai& Van Cuong, Pham…[et al.]. Degalactotigonin, a Steroidal Glycoside from Solanum nigrum, Induces Apoptosis and Cell Cycle Arrest via Inhibiting the EGFR Signaling Pathways in Pancreatic Cancer Cells. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1125646
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1125646