Statins for the Primary Prevention of Coronary Heart Disease
Joint Authors
Shang, Hongcai
Li, Min
Wang, Xiaoli
Li, Xinyi
Chen, Heqing
Hu, Yeyin
Zhang, Xiatian
Tang, Xiaoyi
Miao, Yaodong
Tian, Guihua
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-29
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Object.
The purpose of this study was to fully assess the role of statins in the primary prevention of coronary heart disease (CHD).
Methods.
We searched six databases (PubMed, the Cochrane Library, Web of Science, China National Knowledge Infrastructure, Wanfang Database, and Chinese Scientific Journal Database) to identify relevant randomized controlled trials (RCTs) from inception to 31 October 2017.
Two review authors independently assessed the methodological quality and analysed the data using Rev Man 5.3 software.
Risk ratios and 95% confidence intervals (95% CI) were pooled using fixed/random-effects models.
Funnel plots and Begg’s test were conducted to assess publication bias.
The quality of the evidence was evaluated using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach.
Results.
Sixteen RCTs with 69159 participants were included in this review.
Statins can effectively decrease the occurrence of angina (RR=0.70, 95% CI: 0.58~0.85, I2 =0%), nonfatal myocardial infarction (MI) (RR=0.60, 95% CI: 0.51~0.69, I2 =14%), fatal MI (RR=0.49, 95% CI: 0.24~0.98, I2 =0%), any MI (RR=0.53, 95% CI: 0.42~0.67, I2 =0%), any coronary heart events (RR=0.73, 95% CI: 0.68~0.78, I2=0%), coronary revascularization (RR=0.66, 95% CI: 0.55~0.78, I2 = 0%), and any cardiovascular events (RR=0.77, 95% CI: 0.72~82, I2 = 0%).
However, based on the current evidence, there were no significant differences in CHD deaths (RR=0.82, 95% CI: 0.66~1.02, I2=0%) and all-cause mortality (RR=0.88, 95% CI: 0.76 ~1.01, I2 =58%) between the two groups.
Additionally, statins were more likely to result in diabetes (RR=1.21, 95% CI: 1.05~1.39, I2 =0%).
There was no evidence of publication biases, and the quality of the evidence was considered moderate.
Conclusion.
Statins seemed to be beneficial for the primary prevention of CHDs but have no effect on CHD death and all-cause mortality.
American Psychological Association (APA)
Li, Min& Wang, Xiaoli& Li, Xinyi& Chen, Heqing& Hu, Yeyin& Zhang, Xiatian…[et al.]. 2019. Statins for the Primary Prevention of Coronary Heart Disease. BioMed Research International،Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1125667
Modern Language Association (MLA)
Li, Min…[et al.]. Statins for the Primary Prevention of Coronary Heart Disease. BioMed Research International No. 2019 (2019), pp.1-15.
https://search.emarefa.net/detail/BIM-1125667
American Medical Association (AMA)
Li, Min& Wang, Xiaoli& Li, Xinyi& Chen, Heqing& Hu, Yeyin& Zhang, Xiatian…[et al.]. Statins for the Primary Prevention of Coronary Heart Disease. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1125667
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1125667