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Diagnostic Accuracy of the Xpert MTBRIF Assay for Lymph Node Tuberculosis: A Systematic Review and Meta-Analysis
Joint Authors
Yu, Guocan
Zhong, Fangming
Ye, Bo
Xu, Xudong
Chen, Da
Shen, Yanqin
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-05-19
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Objectives.
To evaluate the performance of Xpert MTB/RIF for lymph node tuberculosis (LNTB).
Methods.
We searched databases for published reports.
We reviewed the studies and identified the performance of Xpert MTB/RIF with respect to a composite reference standard (CRS) and culture.
We used a bivariate random-effects model to perform meta-analyses and used metaregression to analyze sources of heterogeneity.
Results.
15 independent studies compared Xpert MTB/RIF with CRS while 21 comparing it with culture were included.
The pooled sensitivity and specificity of Xpert MTB/RIF were 79% and 98% compared to that of CRS, respectively, and 84% and 91% compared to that of culture, respectively.
The pooled sensitivity and specificity using fine needle aspiration (FNA) samples versus CRS were 80% and 96%, whereas those against culture were 90% and 89%, respectively.
The percentages while working with tissue samples versus CRS were 76% and 100%, respectively, whereas those against culture were 76% and 92%, respectively.
There was no significant difference in diagnostic efficiency among the types of specimen.
Conclusions.
Xpert MTB/RIF demonstrates good diagnostic efficiency for LNTB and is not related to the type of specimen, obtained via different routes.
American Psychological Association (APA)
Yu, Guocan& Zhong, Fangming& Ye, Bo& Xu, Xudong& Chen, Da& Shen, Yanqin. 2019. Diagnostic Accuracy of the Xpert MTBRIF Assay for Lymph Node Tuberculosis: A Systematic Review and Meta-Analysis. BioMed Research International،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1125677
Modern Language Association (MLA)
Yu, Guocan…[et al.]. Diagnostic Accuracy of the Xpert MTBRIF Assay for Lymph Node Tuberculosis: A Systematic Review and Meta-Analysis. BioMed Research International No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1125677
American Medical Association (AMA)
Yu, Guocan& Zhong, Fangming& Ye, Bo& Xu, Xudong& Chen, Da& Shen, Yanqin. Diagnostic Accuracy of the Xpert MTBRIF Assay for Lymph Node Tuberculosis: A Systematic Review and Meta-Analysis. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1125677
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1125677