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Deletion of NAD(P)H Oxidase 2 Prevents Angiotensin II-Induced Skeletal Muscle Atrophy
Joint Authors
Kadoguchi, Tomoyasu
Takada, Shingo
Yokota, Takashi
Furihata, Takaaki
Matsumoto, Junichi
Tsuda, Masaya
Mizushima, Wataru
Fukushima, Arata
Kinugawa, Shintaro
Okita, Koichi
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-02
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Skeletal muscle atrophy is induced by an imbalance between protein synthesis and degradation.
Our previous studies reported that angiotensin II (AII) directly induced muscle atrophy in mice.
This study investigated the role of NAD(P)H oxidase 2 (Nox2) activation by AII in the induction of skeletal muscle atrophy.
For 4 weeks, either saline (vehicle: V) or AII (1000 ng kg−1 min−1) was infused into male wild-type (WT) and Nox2 knockout (KO) mice via osmotic minipumps.
Experiments were performed in the following 4 groups: WT + V, KO + V, WT + AII, and KO + AII.
Body weight, muscle weight, and myocyte cross-sectional area were significantly decreased in WT + AII compared to WT + V mice, and these changes were not observed in KO + AII mice.
Akt phosphorylation of Ser473 and p70S6K of Thr389 was decreased, gene expression levels of MuRF-1 and atrogin-1 were increased in WT + AII compared to WT + V, and these changes were significantly attenuated in KO + AII mice.
The deletion of Nox2 prevented AII-induced skeletal muscle atrophy via improving the balance between protein synthesis and degradation.
Therefore, Nox2 may be a therapeutic target for AII-induced skeletal muscle atrophy.
American Psychological Association (APA)
Kadoguchi, Tomoyasu& Takada, Shingo& Yokota, Takashi& Furihata, Takaaki& Matsumoto, Junichi& Tsuda, Masaya…[et al.]. 2018. Deletion of NAD(P)H Oxidase 2 Prevents Angiotensin II-Induced Skeletal Muscle Atrophy. BioMed Research International،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1125696
Modern Language Association (MLA)
Kadoguchi, Tomoyasu…[et al.]. Deletion of NAD(P)H Oxidase 2 Prevents Angiotensin II-Induced Skeletal Muscle Atrophy. BioMed Research International No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1125696
American Medical Association (AMA)
Kadoguchi, Tomoyasu& Takada, Shingo& Yokota, Takashi& Furihata, Takaaki& Matsumoto, Junichi& Tsuda, Masaya…[et al.]. Deletion of NAD(P)H Oxidase 2 Prevents Angiotensin II-Induced Skeletal Muscle Atrophy. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1125696
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1125696