A Clinical Study of Toxication Caused by Carbamazepine Abuse in Adolescents
Joint Authors
Liu, Chun-Feng
Xu, Wei
Chen, Yu-Lin
Zhao, Ying
Wang, Li-Jie
Li, Jiu-Jun
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-22
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Carbamazepine is known to produce the side effect of euphoria.
As such, it lends itself to being a drug of abuse, particularly in the adolescent population.
This retrospective study evaluated carbamazepine abuse, treatment course, and associated morbidity in Chinese adolescents.
The median dose of carbamazepine resulting in overdose was 2,000 mg (800–5,000).
Patients were largely from urban-rural fringe areas (76.47%, 52.94%) with school performance within the last 1/3 range and (52.94%) unsupervised by parents.
35.29% experienced an obvious sense of euphoria.
All patients had nervous system symptoms, 6 (35.29%) cases developed coma (GCS < 8), and 5 (29.41%) cases experienced convulsion.
Four cases were treated with hemodialysis.
The incidence rate in young patients with repeat carbamazepine use and without the supervision of parents was higher than that in first-time users (5/7 versus 4/10), but the difference was not significant.
The toxic dose of repeat users was 3428 ± 1035 mg, significantly higher than that of 1470 ± 646 mg in first-time users (P=0.001).
Carbamazepine can produce a sense of euphoria, which is more likely to lead to its abuse and overdose in adolescents.
To prevent carbamazepine abuse and overdose will be critical in educating at-risk adolescents and preventing associated morbidities in the future.
American Psychological Association (APA)
Xu, Wei& Chen, Yu-Lin& Zhao, Ying& Wang, Li-Jie& Li, Jiu-Jun& Liu, Chun-Feng. 2018. A Clinical Study of Toxication Caused by Carbamazepine Abuse in Adolescents. BioMed Research International،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1125705
Modern Language Association (MLA)
Xu, Wei…[et al.]. A Clinical Study of Toxication Caused by Carbamazepine Abuse in Adolescents. BioMed Research International No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1125705
American Medical Association (AMA)
Xu, Wei& Chen, Yu-Lin& Zhao, Ying& Wang, Li-Jie& Li, Jiu-Jun& Liu, Chun-Feng. A Clinical Study of Toxication Caused by Carbamazepine Abuse in Adolescents. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1125705
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1125705