Clinical Features, Outcomes, and Risk Factors of Bloodstream Infections due to Stenotrophomonas maltophilia in a Tertiary-Care Hospital of China: A Retrospective Analysis
Joint Authors
Liu, Yunxi
Suo, Jijiang
Du, Mingmei
Chen, Yibing
Chen, Liangan
Wang, Leili
Liang, Zhixin
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-09
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Stenotrophomonas maltophilia bacteremia (SMB) is the most perilous situation as compared to other types of S.
maltophilia infection.
The present study aimed to investigate the clinical features, distribution, drug resistance, and predictors of survival of SMB in a tertiary-care hospital of China.
Methods.
SMB that occurred in a tertiary-care hospital in Beijing, China, within 9 years (2010–2018) was investigated in a retrospective study.
Demographics, incidence, commodities, drug resistance, mortality, as well as antibiotics administration were summarized according to the electronic medical records.
The risk factors for survival were analyzed by Chi-square test, Kaplan–Meier curve and Cox regression.
Results.
A total of 76 episodes of SMB were analyzed.
The overall incidence of SMB fluctuated from 3.4 to 15.4 episodes per 1000 admissions over 9 years.
Malignancy was the most common comorbidity.
High in vitro sensitivity was observed to minocycline (96.1%), levofloxacin (81.6%), and trimethoprim-sulfamethoxazole (89.5%).
Central venous catheter (CVC) (p=0.004), mechanical ventilation (MV) (p=0.006), hemodialysis (p=0.024), and septic shock (p=0.016) were significantly different between survival and death group.
The 30-day mortality was 34.2% within 30 days after confirmation of blood culture.
Factors such as hemodialysis (OR 0.287, 95% CI: 0.084–0.977, p=0.046), T-tube (OR 0.160, 95% CI: 0.029–0.881, p=0.035), and septic shock (OR 0.234, 95% CI: 0.076–0.719, p=0.011) were associated with survival.
Conclusions.
S.
maltophilia is the major nosocomial blood stream infectious pathogenic bacteria.
Trimethoprim-sulfamethoxazole and minocycline are optimal antibiotics for the treatment of SMB.
T-tube, hemodialysis, and septic shock were the risk factors associated with survival of SMB patients.
American Psychological Association (APA)
Chen, Yibing& Suo, Jijiang& Du, Mingmei& Chen, Liangan& Liu, Yunxi& Wang, Leili…[et al.]. 2019. Clinical Features, Outcomes, and Risk Factors of Bloodstream Infections due to Stenotrophomonas maltophilia in a Tertiary-Care Hospital of China: A Retrospective Analysis. BioMed Research International،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1125713
Modern Language Association (MLA)
Chen, Yibing…[et al.]. Clinical Features, Outcomes, and Risk Factors of Bloodstream Infections due to Stenotrophomonas maltophilia in a Tertiary-Care Hospital of China: A Retrospective Analysis. BioMed Research International No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1125713
American Medical Association (AMA)
Chen, Yibing& Suo, Jijiang& Du, Mingmei& Chen, Liangan& Liu, Yunxi& Wang, Leili…[et al.]. Clinical Features, Outcomes, and Risk Factors of Bloodstream Infections due to Stenotrophomonas maltophilia in a Tertiary-Care Hospital of China: A Retrospective Analysis. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1125713
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1125713